Convenient preparation of synthetically useful chiral quaternary carbon-containing bicyclic compounds with organocatalysts

Chiral quaternary carbon-containing bicyclic compounds possessing carbonyl functionalities were effi-ciently synthesized through asymmetric intramolecular aldol reactions with organocatalysts. Bicyclo [3.3.0] and [3.4.0] systems were constructed with a diamine catalyst, while bicyclo [4.3.0] and [4.4.0] skeletons were prepared by an acylsulfonamide type catalyst. (c) 2021 Elsevier Ltd. All rights reserved.

Automated summary

Chiral quaternary carbon-containing bicyclic compounds with carbonyl functionalities were efficiently synthesized through asymmetric intramolecular aldol reactions using organocatalysts. Different types of catalysts were used to construct different bicyclic systems.