期刊
TETRAHEDRON
卷 104, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2021.132599
关键词
Aspergillus niger; Symbiotic fungus; Sesquiterpenoids; Nigerin; Ochracenes J-L
资金
- National Natural Science Foundation of China [82022068, 22137006]
- Two-Hundred Talents Program in School of Medicine, Shanghai Jiao Tong University [20191811]
- Innovative Research Team of High-Level Local Universities in Shanghai
Four new sesquiterpenoids were isolated from a marine sponge collected from the South China Sea. One of the compounds, nigerin, has a unique carbon skeleton and showed potent biological activity.
Four new sesquiterpenoids, nigerin (1) and ochracenes JeL (2-4), were isolated from a symbiotic fungus Aspergillus niger of a marine sponge Dysidea sp. collected from the South China Sea. Nigerin (1) possesses an unprecedented 1-(3-n-pentyl)-2,5,6-trimethyl-cycloheptane carbon skeleton, which represents a new type sesquiterpene scaffold. Ochracenes JeL (2-4) are three new humulane-derived sesquiterpenoids. The structures of 1-4 were elucidated by a combination of 1D and 2D NMR and HRMS analyses, and their absolute configurations were assigned by Mosher's method and ECD calculations. Among the four isolates, nigerin (1) and ochracene J (2) showed potent inhibitory activity on the production of nitric oxide (NO) in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages with IC50 values of 8.5 and 4.6 mM, respectively. (C) 2021 Published by Elsevier Ltd.
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