Relationship of visceral obesity and coronary calcinosis in ischemic heart disease

Aim. To assess the relationship between the prevalence of visceral obesity (VO) and the severity of coronary calcification (CC) in patients with verified coronary artery disease (CAD). Materials and method. 125 patients with CAD were examined. Assessment of the morphometric characteristics of visceral adipose tissue (VAT) and CC was perform using multislice computed tomography (MSCT). The calcium index (CI) of the coronary arteries (CA) was determine by the Agatston method. Statistical analysis was perform using Statistica 10.0. Result. VO was detect in 82 (65.6%) patients with CAD. In the presence of VO, higher CC values were observed in the projection of the envelope (p=0.00014), right coronary (p=0.00002) arteries, total CI (p=0.0003), and the prevalence of massive CC. Correlation analysis showed the relationship between the area of VAT and the CC of all the studied localizations. According to the ROC analysis, VO is a significant predictor of massive CC (area under the ROC curve - AUC 0.72, 95% CI 0.56-0.89), in contrast to body mass index - BMI (AUC 0.56, 95% CI 0.31-0.82). Conclusion. The index of the ratio of VAT to subcutaneous adipose tissue (VAT/SAT), but not BMI, had a direct correlation with CC. Morphology of VAT may be a significant diagnostic sign of massive CC in patients with CAD, as a factor affecting treatment and prognosis.

Automated summary

This study assessed the relationship between visceral obesity (VO) prevalence and coronary calcification (CC) severity in patients with verified CAD. The study found that the VAT/SAT index had a direct correlation with CC, indicating that VAT morphology could be an important diagnostic sign of massive CC in CAD patients, affecting treatment and prognosis.