4.7 Article

Development of a simple and rapid screening method for the detection of 1-(3-chlorophenyl)piperazine in forensic samples

期刊

TALANTA
卷 233, 期 -, 页码 -

出版社

ELSEVIER
DOI: 10.1016/j.talanta.2021.122597

关键词

Novel psychoactive substances; Forensic chemistry; On-site analysis; Piperazine; Square-wave voltammetry

资金

  1. FAPEMIG [PPM-00614-18, PPM-0014218, APQ-03637-16 RED-00042-16]
  2. CNPq [308504/2018-6, 424432/2018-8, 206071/2017-5, 307271/2017-0]
  3. CAPES [001]
  4. INCTBio (CNPq) [465389/2014-7]

向作者/读者索取更多资源

The study presents a portable electrochemical method for the rapid and simple detection of mCPP in seized samples, showing a linear correlation with low detection limit, with potential to be a screening tool for mCPP in forensic samples.
1-(3-chlorophenyl) piperazine (mCPP) is a synthetic drug with hallucinogenic effects that has often been found in seized samples. In this context, easy to use point-of-care tests can be of great value in preliminary forensic analysis. Herein, we proposed a simple, fast, and portable electrochemical method for the detection of mCPP in seized samples. The method is based on the use of disposable screen-printed carbon electrodes (SPCE) and rapid screening procedures by square-wave voltammetry using minimal sample sizes (100 mu L). mCPP showed an irreversible electrochemical oxidation process at +0.65 V on SPCE (vs Ag) using 0.04 mol L-1 Britton Robinson (BR) buffer solution (pH 7) as the supporting electrolyte. The proposed method exhibited a linear correlation (r = 0.998) between peak current and mCPP concentration in the range of 1-30 mu mol L-1 (LOD = 0.1 mu mol L-1). Interference studies were performed for adulterants and other classes of drugs of abuse, which can also be found in seized samples containing mCPP, such as caffeine, amphetamine, methamphetamine, 1-benzylpiperazine, 3,4-methylenedioxymethamphetamine, methylone, mephedrone, ethylone and 3, 4-methylenedioxypyrovalerone. The developed method presents great potential as a rapid and simple screening tool to detect mCPP in forensic samples.

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