期刊
TALANTA
卷 237, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.talanta.2021.122925
关键词
4-Methylimidazole; Derivatization reaction; Surface-enhanced Raman scattering; Ratiometric strategy
A simple and efficient SERS method with ratiometric strategy was developed for the detection of 4-MI. The method showed high sensitivity and reliability, making it suitable for determination of compounds containing active hydrogen atoms.
Herein, a facile and fast surface-enhanced Raman scattering (SERS) method with ratiometric strategy was developed for detection of 4-methylimidazole (4-MI). Via a chemical derivatization reaction with 3-amino-5-mercapto-1,2,4-triazole (AMTA) diazonium salts, 4-MI could be converted to SERS-sensitive species. The SERS intensity ratio between the peaks at 1243 cm(-1) and 1110 cm(-1) (I-1243/I-1110) was used for the quantification of 4-MI. In addition, the method sensitivity was further improved by the aggregation of beta-cyclodextrin-modified Ag nanoparticles (beta-CD-AgNPs). Under the optimal conditions, the limit of detection (LOD) and the limit of quantification (LOQ) for 4-MI were 1.7 nM (S/N = 3) and 5.7 nM (S/N = 10), respectively. The relative standard deviation (RSD) for 0.5 mu M 4-MI was 8.2% (n = 20). This method was successfully used for the determination of 4-MI in cola samples with recoveries ranging from 92% to 106%. The present method is convenient, sensitive, selective, reliable and may have a promising application in determination of the compounds with an imidazole ring containing active hydrogen atoms.
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