The synthesis of phenyl carbamates catalyzed by iron (II) bromide: An oxidative approach for cross-coupling of phenols with formamides

The carbamate group is a key structural motif in many approved drugs and pro-drugs. There is increasing use of carbamates in the medicinal chemistry and agrochemical industry. We present, reagents and chemical methodologies for the synthesis of carbamates, and recent applications. The direct coupling of simple phenols with mono- and di-alkyl formamides provided the phenylcarbamate products.

Automated summary

The carbamate group is commonly found in approved drugs and pro-drugs, and its use is increasing in medicinal chemistry and agrochemical industry. A method for synthesizing phenylcarbamate products by directly coupling simple phenols with mono- and di-alkyl formamides is presented.