Electrochemical bromolactonization of alkenoic acids with carbon tetrabromide: Synthesis of bromomethylated γ-lactones

Electrochemical radical bromination and cyclization sequences of alkenoic acids developed in this study. This approach is environmental-friendly by using carbon tetrabromide as a bromine radical precursor. The electrochemical protocol offers a facile way to prepare bromomethylated gamma-lactones derivatives in moderate to high yields. [GRAPHICS] .

Automated summary

This study presents the development of an electrochemical method for bromination and cyclization reactions, which offers an environmentally friendly approach and enables efficient synthesis of bromomethylated gamma-lactone derivatives.