4.5 Article

Transition-Metal-Catalyzed Decarbonylative Functionalization of Phthalimides

期刊

SYNTHESIS-STUTTGART
卷 54, 期 11, 页码 2561-2573

出版社

GEORG THIEME VERLAG KG
DOI: 10.1055/a-1751-1929

关键词

decarbonylation reactions; phthalimides; amides; C-N bond activation; isoquinolones; alkynes; alkenes

资金

  1. National Natural Science Foundation of China [21971234, 21772194, 21572225]

向作者/读者索取更多资源

Phthalimide derivatives, commonly found in biologically important molecules, have attracted considerable attention for their potential applications in drug development, fungicides, and anticancer agents. This review focuses on recent advances in catalytic strategies for directly modifying the phthalimide moiety, including decarbonylation and derivatization reactions. Various decarbonylative addition reactions, polymerization, alkylation, arylation, and protodecarbonylation reactions have been demonstrated. The review also discusses the mechanisms involved and highlights the importance of further developments in this field.
Phthalimide derivatives are prevalent in a wide array of biologically important molecules, including drugs, fungicides, and anticancer molecules. Thus, catalytic methods that directly edit the phthalimide moiety, in particular, decarbonylation and derivatization, could be strategically valuable for the modification of existing phthalimide molecular scaffolds. In recent years, considerable efforts have been devoted to emulating the transition- metal-catalyzed phthalimide decarbonylative reaction. A set of elegant strategies, including decarbonylative addition reactions with alkynes, alkenes, and benzynes, decarbonylative polymerization, alkylation, arylation, and protodecarbonylation, have been demonstrated. This review aims to highlight these advances and discusses the mechanism issues, to further expand application and promote developments in this field. 1 Introduction 2 Decarbonylative Addition Reaction with Alkynes 3 Decarbonylative Addition Reaction with Alkenes 4 Decarbonylative Addition Reaction with Benzyne 5 Decarbonylative Polymerization 6 Decarbonylative Alkylation 7 Decarbonylative Arylation 8 Protodecarbonylation 9 Conclusion and Outlook

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据