期刊
SYNLETT
卷 33, 期 5, 页码 488-494出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/a-1747-2724
关键词
Mannich reaction; 3-fluorooxindoles; alpha-fluoro-beta-amino-oxindoles; quinine-derived skeleton; urea-catalyzed catalysts
资金
- National Natural Science Foundation of China [51373067]
In this study, a chiral urea catalyst derived from quinine was used to catalyze the asymmetric Mannich reaction of 3-fluorooxindoles and alpha-amidosulfones. The reaction yielded alpha-fluoro-beta-amino-oxindoles with a tertiary carbon stereocenter in high yields (up to 95%) and exhibited high enantioselectivity (95%) and diastereoselectivity (>99:1). These alpha-fluoro-beta-amino-oxindole compounds are potential candidates in the field of medicine.
The asymmetric Mannich reaction of 3-fluorooxindoles and alpha-amidosulfones catalyzed by a chiral urea catalyst derived from quinine in presence of K3PO4 was developed. Through the asymmetric reaction, a series of alpha-fluoro-beta-amino-oxindoles, containing a tertiary carbon stereocenter, could be obtained in high yields (up to 95%) with high enantioselectivity (95%) and diastereoselectivity (>99:1). Such alpha-fluoro-beta-amino-oxindole compounds are expected to become candidates in the field of medicine.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据