Calcium phosphate composites to synergistically promote osteoconduction and corrosion resistance on bone materials via plasma polymerized hexamethyldisilazane coatings

A facile and effective plasma polymerized hexamethyldisilazane (ppHMDSZ) combining with calcium phosphate (Ca-P) coating to promote osteoconduction meanwhile provide resistance to corrosion is developed in this study. The composites of Ca-P and ppHMDSZ thin films were deposited on bone substitutes to investigate the osteoblast compatibility. The amount of the Ca-P coatings was modulated with a linear deposition rate of 7.37 mu g/(cm(2).cycle) by alternative immersion cycles (1, 2, 5, and 10) in solutions containing calcium and phosphate, measured by quartz crystal microbalance (QCM). Importantly, cell behaviors including cell adhesion, proliferation, and functional activity responded positively toward the surface wettability and roughness of the Ca-P layers. Moreover, the human osteoblast cells (hFOB1.19) revealed excellent compatibility on the stainless steel coated with Ca-P/ppHMDSZ composite films. The combination of bioceramics and corrosion resisting plasma polymerized HMDSZ films showed a synergistic effect on the biocompatibility and osteoconductive for bone tissue engineering applications.

Automated summary

A composite material combining calcium phosphate and plasma polymerized HMDSZ has been developed to enhance osteoconduction and corrosion resistance. Modulating the amount of Ca-P coatings showed positive cell responses towards surface wettability and roughness. The combination of bioceramics and corrosion resistant plasma polymerized HMDSZ films exhibited synergistic effects on biocompatibility and osteoconductivity for bone tissue engineering applications.