☆ 4.7 Editorial Material

How CEP164 ciliopathy mutations impair ciliogenesis

STRUCTURE (2022)

Molecular mechanisms underlying the role of the centriolar CEP164-TTBK2 complex in ciliopathies

Ivan Rosa e Silva et al.

Summary: This study provides a detailed analysis of the CEP164-TTBK2 complex and demonstrates how it is affected by ciliopathic mutations in CEP164. Moreover, insights into the coordination between binding to CEP164 and TTBK2 activities are also revealed.

STRUCTURE (2022)

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Article Biochemistry & Molecular Biology

How the centriole builds its cilium: of mothers, daughters, and the acquisition of appendages

Dhivya Kumar et al.

Summary: Centrioles are microtubule-based structures in eukaryotic cells that play crucial roles in organizing the cell's cytoskeleton and facilitating various cellular processes. One important function of centrioles is to assemble cilia, which are involved in sperm locomotion, mucus flow in the lung, and intercellular signaling. It is suggested that understanding how centrioles are remodeled to support cilium assembly could provide insights into the molecular etiologies of ciliopathies.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2021)

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Article Multidisciplinary Sciences