期刊
INTERNAL MEDICINE
卷 55, 期 13, 页码 1769-1774出版社
JAPAN SOC INTERNAL MEDICINE
DOI: 10.2169/internalmedicine.55.6287
关键词
drug-induced hypersensitivity syndrome (DIHS); drug rash with eosinophilia and systemic symptoms (DRESS); eosinophilia; human herpes virus 6 (HHV-6); reactivation
A 74-year-old man who had been administered trimethoprim-sulfamethoxazole for three weeks suffered from drug-induced hypersensitivity syndrome/drug rash with eosinophilia and systemic symptoms (DIHS/DRESS). In the early stage of the clinical course, he developed renal dysfunction. A renal biopsy showed granulomatous tubulointerstitial nephritis accompanying the proliferation of human herpes virus ( HHV)-6 in tubular epithelial cells. With corticosteroid therapy, the systemic rash and renal function gradually improved. The present patient is the second case of DIHS/DRESS demonstrating a possible reactivation of HHV-6 in the renal tissue. The clinical role of viral reactivation in DIHS/DRESS must be further elucidated.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据