期刊
STROKE
卷 53, 期 2, 页码 416-426出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/STROKEAHA.120.032611
关键词
Alzheimer disease; brain; biomarkers; cerebrovascular disease; cognition; dementia
资金
- National Institutes of Health [R01 NS097495, R01 AG056366, P30 AG010129, R01 AG047827, R01 AG 031563, UH3 NS100608, U19 NS 120384]
This focused review provides an update on current magnetic resonance imaging methods for measuring cerebrovascular disease lesions and early cerebrovascular disease-related brain injury. It discusses the clinical implications and relevance of these imaging markers for cognitive decline, incident dementia, and disease progression in Alzheimer's disease and related dementias. The review also presents the outlook and challenges in the field.
Cerebrovascular disease (CVD) manifests through a broad spectrum of mechanisms that negatively impact brain and cognitive health. Oftentimes, CVD changes (excluding acute stroke) are insufficiently considered in aging and dementia studies which can lead to an incomplete picture of the etiologies contributing to the burden of cognitive impairment. Our goal with this focused review is 3-fold. First, we provide a research update on the current magnetic resonance imaging methods that can measure CVD lesions as well as early CVD-related brain injury specifically related to small vessel disease. Second, we discuss the clinical implications and relevance of these CVD imaging markers for cognitive decline, incident dementia, and disease progression in Alzheimer disease, and Alzheimer-related dementias. Finally, we present our perspective on the outlook and challenges that remain in the field. With the increased research interest in this area, we believe that reliable CVD imaging biomarkers for aging and dementia studies are on the horizon.
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