Uncertainties and Controversies in the Management of Ischemic Stroke and Transient Ischemic Attack Patients With Patent Foramen Ovale

Multiple randomized clinical trials have demonstrated the benefit of patent foramen ovale closure over medical therapy alone for patients who have had a stroke that has been attributed to the patent foramen ovale. Nevertheless, there are many areas of uncertainty and controversy related to patient selection, pathophysiology, diagnosis, and treatment. We summarize the available data on these challenging topics and attempt to provide some clarity and future directions for clinicians and investigators.

Automated summary

This study summarizes the available data on the benefits of patent foramen ovale closure over medical therapy for patients who have had a stroke attributed to the patent foramen ovale. Despite uncertainties and controversies in patient selection, pathophysiology, diagnosis, and treatment, this study aims to provide clarification and future directions for clinicians and investigators.