Generation and characterization of an induced pluripotent stem cell line (FJMUNi001-A) from a patient with Duchenne muscular dystrophy carrying c.4518+512 T > A variant in the DMD gene

Duchenne muscular dystrophy (DMD) is an X-linked recessive degenerative disease characterized by progressive weakness of limbs. In this study, we generated an induced pluripotent stem cell line from a DMD patient's dermal fibroblasts with non-integrating Sendai virus. The patient carried a rare c.4518 + 512 T > A variant in the DMD gene. This iPSC line displayed normal iPSC morphology, karyotypes and pluripotency expression markers, and also can be differentiated into the three germ layers.

Automated summary

In this study, an induced pluripotent stem cell line was generated from a DMD patient's dermal fibroblasts using non-integrating Sendai virus. This iPSC line exhibited normal iPSC characteristics and could differentiate into the three germ layers.