期刊
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
卷 265, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.saa.2021.120390
关键词
Fluorescent probe; Hydrogen sulfide; Excited-state intramolecular proton transfer; Mitochondria-targeting
类别
资金
- Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi [2020L0545]
- Xinzhou Teachers University Fund [2019KY09]
- Xinzhou Teachers University PhD startup fund [00000460]
- Fund for Shanxi 1331 Project Key Subjects Construction
- Top Science and Technology Innovation Teams of Xinzhou Teachers University
The designed fluorescent probe HBTP-H2S based on ESIPT effect showed fast response time, good selectivity and a large Stokes shift towards H2S, and was successfully employed to monitor mitochondrial H2S in HepG2 cells.
Excited-state intramolecular proton transfer (ESIPT) has recently received considerable attention due to its dual fluorescent changes and large Stokes shift. Hydrogen sulfide (H2S) is a gas signal molecule that plays important roles in modulating the functions of different systems. Herein, by modifying 2-(2-hydroxyphenyl) benzothiazole (HBT) scaffold, a novel near-infrared mitochondria-targeted fluorescent probe HBTP-H2S has been rationally designed based on excited-state intramolecular proton transfer (ESIPT) effect. The nucleophilic addition reaction of the H2S with probe HBTP-H2S caused the break of the conjugated skeleton, resulting the shifting of maximum emission peak from 658 nm to 470 nm. HBTP-H2S showed fast-response response time, good selectivity and a large Stokes shift (188 nm) toward H2S. Most importantly, inspired by the inherent advantages of the probe, HBTP-H2S was successfully employed to monitor mitochondrial H2S in HepG2 cells. (C) 2021 Published by Elsevier B.V.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据