期刊
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
卷 262, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.saa.2021.120134
关键词
Sulfur dioxide; Hydrogen peroxide; Long-wavelength probe; Reversible detection; Redox state
类别
资金
- National Natural Science Foundation of China [21977060, 21702116]
- Shandong Provincial Key Research and Development Program, China [2019GSF107087, 2019GSF107078]
- Qingdao Municipal Science and Technology Bureau, China [196232cg]
- Project of Shandong Province Higher Educational Science and Technology Program, China [J18KA079]
The study introduced a long-wavelength fluorescent probe with high selectivity and sensitivity to reversibly monitor sulfur dioxide and hydrogen peroxide in living cells. The probe could accumulate in mitochondria for real-time imaging of SO2/H2O2, making it an ideal tool for monitoring the redox cycle state in living cells.
Studies have shown that changes in the redox state of cells might be closely related to pathological and physiological processes. Sulfur dioxide and hydrogen peroxide, as a significant redox couple in living cells, are endogenously produced by cells. Here, we report a long-wavelength fluorescent probe to reversibly monitor sulfur dioxide and hydrogen peroxide. This probe (NBD) displayed high selectivity and sensitivity, which could be accumulated in mitochondria for real-time imaging of SO2/H2O2. These results indicated that NBD would be an ideal tool for monitoring the redox cycle state in living cells. (C) 2021 Elsevier B.V. All rights reserved.
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