4.7 Article

A fluorogenic H2S donor activated by reactive oxygen species for real-time monitoring in cells and in vivo

出版社

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.saa.2021.120243

关键词

Fluorescent monitoring; Hydrogen sulfide; Fluorescent donor; Naphthalimides

资金

  1. National Natural Science Foundation of China [21908032]
  2. Natural Science Foundation Program of Guangxi Province [2018GXNSFBA281194]
  3. Science and Technology Planning Project of Guangxi [2020AC19096]
  4. Foundation of Guangxi Educational Committee [20190KY0321]

向作者/读者索取更多资源

Hydrogen sulfide (H2S) is a crucial gasotransmitter in biological systems and is widely used in biological studies. A newly developed donor molecule, HSD545, triggers the release of H2S in response to reactive oxygen species (ROS) and simultaneously generates a fluorescent substance for real-time monitoring. The donor exhibits low cytotoxicity and provides strong cytoprotection against ROS-induced oxidative stress.
Hydrogen sulfide (H2S) is an important gasotransmitter in biological system, and plays a crucial role in varied physiological and pathological processes. Exogenous H2S is widely employed as a positive control in H2S related biological study. Herein, we develop a reactive oxygen species (ROS) triggered donor HSD545 that delivers H2S and simultaneously generates a fluorophore to real-time monitoring the process of H2S release in vitro and in vivo. The donor exhibits low cytotoxicity and strong cytoprotection against ROS-induce oxidative stress. (C) 2021 Elsevier B.V. All rights reserved.

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