期刊
SOUTHERN AFRICAN JOURNAL OF HIV MEDICINE
卷 22, 期 1, 页码 -出版社
AOSIS
DOI: 10.4102/sajhivmed.v22i1.1312
关键词
HIV; antiretroviral therapy; tuberculosis; spirometry; sub-Saharan Africa; obstructive lung disorder; COPD; asthma; pulmonary function
资金
- Boehringer Ingelheim the Netherlands
The study found that HIV infection and ART use were not associated with reduced pulmonary function in an urban African population in Johannesburg, South Africa. Tuberculosis played a mediating role in the relationship between HIV, ART, and pulmonary function.
Background: With the roll-out of antiretroviral treatment (ART), the life expectancy of people with HIV and, hence, morbidity from non-communicable diseases, including pulmonary diseases, have increased. Objectives: This research study aims to investigate whether HIV infection and ART use are associated with pulmonary function, given the high frequency of pulmonary infections, including tuberculosis (TB), associated with HIV. Method: Adults living with HIV (ART-naive, on first- or second-line ART), and age and sex matched HIV-negative controls were included in a cross-sectional study in Johannesburg, South Africa. Spirometry was performed to determine lung function, measuring the forced expiratory volume in one second (FEV1), the forced vital capacity (FVC) and the FEV1/FVC ratio before (pre), and after (post), short-acting bronchodilator. The association of HIV infection and ART use with pulmonary function was analysed using linear regression models, adjusting for age, gender, body surface area (BSA), employment, education, smoking and TB. Results: Overall, 548 participants (62% women) were included with a mean age of 38 (standard deviation [s.d.] 9.5) years. No effect of HIV or ART on post-FEV1 was observed in adjusted analysis. Additional adjustment for TB resulted in a higher post-FEV1 in participants on ART compared with HIV-negative participants, whereas TB was associated with a lower FEV1. No effect of HIV and ART on post-FEV1/FVC was observed. Conclusion: HIV infection and ART use were not associated with reduced pulmonary function in this urban African population. Tuberculosis showed a mediating effect on the association between HIV, ART and pulmonary function.
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