期刊
SOUTH AFRICAN JOURNAL OF BOTANY
卷 142, 期 -, 页码 149-155出版社
ELSEVIER
DOI: 10.1016/j.sajb.2021.06.023
关键词
Antibacterial activity; Antioxidant activity; A. officinalis; Mangrove plants; GC-MS analysis
资金
- Ministry of Environment, Forest and Climate Change, Government of India
- World Bank under the India ICZM Project
The study analyzed the bioactive compounds in the ethyl acetate leaves extract of Avicennia officinalis and found strong antibacterial and antioxidant activity against various bacteria. The natural products present in Avicennia officinalis showed promising potential in the formulation of therapeutic drugs against bacterial infections, antioxidants, and cancer.
Avicennia officinalis L. is an important mangrove plant used in traditional medicine to treat various diseases like asthma, dyspepsia, paralysis, tumor and rheumatism in aboriginal peoples in Andaman and Nicobar Islands (ANI). The study analyzed and separated bioactive speciation of ethyl acetate leaves extract of A. officinalis from tropical mangrove plants by Gas Chromatography-Mass Spectrometry (GCMS) and further antimicrobial and antioxidant potential assay. GC-MS results of A. officinalis identified eight different bioactive compounds namely Trans-cinnamic acid, 2,4-Di-tert-butyl phenol, Phenol, 3-(2phenylethyl, n-hexadecanoic acid, Dibutyl phthalate, Phytol, beta-Sitosterol, Androst-7-ene-6, 17-dione and 2,3,14-trihydroxy. The natural products present in A. officinalis showed strong antibacterial activity against different bacteria like gram-positive strain: Streptococcus mutans (19 mm maximum zone of inhibition), Bacillus subtilis (17 mm), Pseudomonas aeruginosa (16 mm), and gram-negative: Klebsiella pneumonia (22 mm) and Enterobacter aerohenes (14 mm). Further, this crude extract showed good antioxidant activity with IC50 values of 23.60 +/- 0.43 mu g/ml measured using the DPPH method. Thus, the study put forth the promising role of ethyl acetate leaves extract of A. officinalis in the formulation of therapeutic drugs against bacterial infections, antioxidants and cancer. (C) 2021 SAAB. Published by Elsevier B.V. All rights reserved.
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