All-in-One: Multifunctional Hydrogel Accelerates Oxidative Diabetic Wound Healing through Timed-Release of Exosome and Fibroblast Growth Factor

The treatment of diabetic wounds remains a major challenge in clinical practice, with chronic wounds characterized by multiple drug-resistant bacterial infections, angiopathy, and oxidative damage to the microenvironment. Herein, a novel in situ injectable HA@MnO2/FGF-2/Exos hydrogel is introduced for improving diabetic wound healing. Through a simple local injection, this hydrogel is able to form a protective barrier covering the wound, providing rapid hemostasis and long-term antibacterial protection. The MnO2/epsilon-PL nanosheet is able to catalyze the excess H2O2 produced in the wound, converting it to O-2, thus not only eliminating the harmful effects of H2O2 but also providing O-2 for wound healing. Moreover, the release of M2-derived Exosomes (M2 Exos) and FGF-2 growth factor stimulates angiogenesis and epithelization, respectively. These in vivo and in vitro results demonstrate accelerated healing of diabetic wounds with the use of the HA@MnO2/FGF-2/Exos hydrogel, presenting a viable strategy for chronic diabetic wound repair.

Automated summary

The novel HA@MnO2/FGF-2/Exos hydrogel can improve diabetic wound healing by forming a protective barrier and providing long-term antibacterial protection, while utilizing MnO2/ε-PL nanosheets to catalyze H2O2 conversion to O-2, releasing M2 Exos and FGF-2 to promote the healing process.