期刊
SMALL
卷 18, 期 6, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.202104132
关键词
deep tissue imaging; photoacoustic imaging; second near infrared window; semiconducting polymers; surfactant-stripped micelles
类别
资金
- National Key Research and Development Program [2021YFC 2102300]
- National Natural Science Foundation of China [32071384]
- National Research Foundation (NRF) of Korea [2020R1A6A1A03047902, 2019R1A2C2006269]
- National Research Foundation (NRF) of Korea (BK21 FOUR Project)
- Tianjin University, One-thousand Young Talent Program
- National Research Foundation of Korea [2019R1A2C2006269, 2020R1A6A1A03047902, 4199990114297] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
The study introduces a semiconducting polymer with strong absorption in the second near infrared (NIR-II) window, leading to the development of surfactant-stripped semiconductor polymeric micelles (SSS-micelles) with water solubility and high photothermal conversion efficiency for deep tissue imaging and tumor theranostics.
Photoacoustic imaging (PA) in the second near infrared (NIR-II) window presents key advantages for deep tissue imaging owing to reduced light scattering and low background signal from biological structures. Here, a thiadiazoloquinoxaline-based semiconducting polymer (SP) with strong absorption in the NIR-II region is reported. After encapsulation of SP in Pluronic F127 (F127) followed by removal of excess surfactant, a dual functional polymer system named surfactant-stripped semiconductor polymeric micelles (SSS-micelles) are generated with water solubility, storage stability, and high photothermal conversion efficiency, permitting tumor theranostics in a mouse model. SSS-micelles have a wideband absorption in the NIR-II window, allowing for the PA imaging at both 1064 and 1300 nm wavelengths. The PA signal of the SSS-micelles can be detected through 6.5 cm of chicken breast tissue in vitro. In mice or rats, SSS-micelles can be visualized in bladder and intestine overlaid 5 cm (signal to noise ratio, SNR approximate to 17 dB) and 5.8 cm (SNR over 10 dB) chicken breast tissue, respectively. This work demonstrates the SSS-micelles as a nanoplatform for deep tissue theranostics.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据