4.8 Review

Chemodynamic Therapy via Fenton and Fenton-Like Nanomaterials: Strategies and Recent Advances

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Low-Temperature Photothermal Therapy: Strategies and Applications

Xiulin Yi et al.

Summary: This study summarises strategies for achieving low-temperature PTT using nanomaterials, introduces the synthesis, characteristics, and applications of these nanoplatforms, and discusses the synergistic cancer therapeutic effect of combining PTT with other treatment modalities.

RESEARCH (2021)

Article Materials Science, Multidisciplinary

Construction of ferrocene modified and indocyanine green loaded multifunctional mesoporous silica nanoparticle for simultaneous chemodynamic/photothermal/photodynamic therapy

Renlu Han et al.

Summary: The near-infrared light responsive multifunctional nanoparticles, constructed for collaborative chemodynamic/photothermal/photodynamic therapy, show great potential in cancer synergistic treatments by selectively targeting cancer cells and using different components to effectively kill them.

MATERIALS TODAY COMMUNICATIONS (2021)

Article Engineering, Biomedical

Biodegradable BiOCl platform for oxidative stress injury-enhanced chemodynamic/radiation therapy of hypoxic tumors

Yongtian Liu et al.

Summary: The development of a bismuth-based Cu2+-doped BiOCl nanotherapeutic platform that can self-supply H2O2 and enhance oxidative stress for improved tumor therapy was demonstrated. This platform effectively combined chemodynamic therapy with sensitized radiotherapy to achieve synergistic anti-tumor effects.

ACTA BIOMATERIALIA (2021)

Article Chemistry, Multidisciplinary

A Harmless-Harmful Switchable and Uninterrupted Laccase-Instructed Killer for Activatable Chemodynamic Therapy

Tian-Jiao Zhou et al.

Summary: The article introduces a new CDT agent HULK, which activates chemotherapy through LAC-guided generation of O-2(-center dot). By photodegrading the O-2(-center dot) scavenger FeCe6, it achieves a switchable effect from harmless to harmful, enhancing the therapeutic efficacy.

ADVANCED MATERIALS (2021)

Article Chemistry, Multidisciplinary

Pd-Single-Atom Coordinated Biocatalysts for Chem-/Sono-/Photo-Trimodal Tumor Therapies

Fangxue Du et al.

Summary: A novel and facile Pd-single-atom-coordinated porphyrin-based polymeric network for chem-/sono-/photo-trimodal tumor therapies has been designed, showing highly efficient biocatalytic sites and synergistic trimodal therapeutic effects in both in vitro and in vivo experiments.

ADVANCED MATERIALS (2021)

Article Chemistry, Multidisciplinary

Supramolecular Polymerization-Induced Nanoassemblies for Self-Augmented Cascade Chemotherapy and Chemodynamic Therapy of Tumor

Kuikun Yang et al.

Summary: A supramolecular nanoparticle has been developed for chemodynamic therapy, which can release radicals and platinum (IV) prodrug in tumors to enhance H2O2 generation. The nanoparticles can be readily excreted via renal clearance to avoid systemic toxicity, providing potential for novel cascade chemo/chemodynamic therapy.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Article Engineering, Biomedical

Infection microenvironment-activated nanoparticles for NIR-II photoacoustic imaging-guided photothermal/chemodynamic synergistic anti-infective therapy

Nan Yang et al.

Summary: A novel theranostic platform based on Cu2O nanoparticles was successfully constructed, which can precisely identify and eliminate bacteria in the infection microenvironment, showing a good antibacterial effect against drug-resistant bacteria.

BIOMATERIALS (2021)

Article Engineering, Biomedical

Cyclic reactions-mediated self-supply of H2O2 and O2 for cooperative chemodynamic/starvation cancer therapy

Xiaojuan Zhang et al.

Summary: This study developed a novel nanoplatform that co-delivers Fe(OH)3-doped CaO2 nanocomposites and GOx molecules for synergistic chemodynamic therapy and starvation therapy, providing a mutually reinforced modality based on cyclic Fenton/starvation reactions for effective treatment of hypoxic cancers.

BIOMATERIALS (2021)

Article Engineering, Biomedical

One-pot synthesis of AuPd@FexOy nanoagent with the activable Fe species for enhanced Chemodynamic-photothermal synergetic therapy

Yanhong Sun et al.

Summary: The study demonstrates that facile fabrication of Fe-based nanotheranostic agents with enhanced Chemodynamic therapy effects and multiple functions is achievable using a simple redox self-assembly strategy. The core-shell nanoparticles exhibited enhanced production of center dot OH in Fenton reaction when activated, along with a favorable photothermal effect and pH-responsive properties. This work provides an attractive route to prepare versatile nanotheranostic agents for oncotherapy.

BIOMATERIALS (2021)

Review Oncology

Reactive oxygen species in cancer: Current findings and future directions

Hajime Nakamura et al.

Summary: Reactive oxygen species (ROS) play a crucial role in cancer, with low to moderate levels activating cell functions and high levels causing cell death. Therapies manipulating ROS levels show promise for cancer treatment, offering new opportunities for therapeutic strategies.

CANCER SCIENCE (2021)

Article Chemistry, Physical

A glutathione responsive nanoplatform made of reduced graphene oxide and MnO2 nanoparticles for photothermal and chemodynamic combined therapy

Baojin Ma et al.

Summary: The study designed a multifunctional nanoplatform using reduced graphene oxide and manganese dioxide nanoparticles for efficient photothermal and chemodynamic combined therapies in cancer treatment. The nanoplatform enhanced cancer therapy efficiency by depleting GSH and generating ROS.

CARBON (2021)

Article Engineering, Environmental

Biomineralized DNA nanospheres by metal organic framework for enhanced chemodynamic therapy

Peipei Wang et al.

Summary: In this study, metal organic framework (MOF)-biomineralized DNA nanospheres were developed as chemodynamic therapy (CDT) agents with tumor-activable cascade reactions for boosting intracellular H2O2 concentration, achieving remarkable antitumor outcome. The CDT agent utilizes tumor acid-induced dissociation to release Fe2+/Fe3+ for Fenton reaction and GOx for catalyzing glucose into H2O2, synergistically elevating ROS level in tumor cells to induce ferroptosis. This strategy provides a promising approach for developing CDT agents with improved therapeutic efficacy.

CHEMICAL ENGINEERING JOURNAL (2021)

Article Engineering, Environmental

Tumor microenvironment responsive biomimetic copper peroxide nanoreactors for drug delivery and enhanced chemodynamic therapy

Shengxin Hou et al.

Summary: A new type of nano-Fenton catalyst was developed to release H2O2 in the tumor microenvironment and combine with chemotherapy drugs, effectively improving the therapeutic effect of tumors. This new strategy provides a new direction for enhancing chemodynamic therapy and synergistic treatment.

CHEMICAL ENGINEERING JOURNAL (2021)

Article Biophysics

Cu-doped cerium oxide-based nanomedicine for tumor microenvironment-stimulative chemo-chemodynamic therapy with minimal side effects

Fang Cheng et al.

Summary: Cu-doped cerium oxide nanoparticles loaded with doxorubicin and coated with breast cancer cell membrane were designed as a novel antitumor controlled drug release system, showing enhanced peroxidase-mimicking activity in the tumor microenvironment. This system demonstrated selective and nearly complete tumor suppression both in vitro and in vivo, while also protecting normal cells from oxidative stress.

COLLOIDS AND SURFACES B-BIOINTERFACES (2021)

Article Biophysics

CaO2/Fe3O4 nanocomposites for oxygen-independent generation of radicals and cancer therapy

Marhaba Mamat et al.

Summary: The construction of oleylamine coated CaO2/Fe3O4 nanocomposites enables oxygen-independent generation of ROS for efficient cancer treatment in hypoxic tumor environment. The nanoparticles exhibit remarkable tumor growth inhibition ability and favorable biocompatibility at the tumor site.

COLLOIDS AND SURFACES B-BIOINTERFACES (2021)

Article Biophysics

A pH-sensitive drug delivery system based on hyaluronic acid co-deliver doxorubicin and aminoferrocene for the combined application of chemotherapy and chemodynamic therapy

Mengheng Lei et al.

Summary: A pH-responsive drug delivery system (NPs(DOX/AFc)) was developed for codelivery of doxorubicin (DOX) and aminoferrocene (AFc) in tumor therapy, showing reduced dosage of DOX and potential synergistic effects between DOX and AFc. The system demonstrated increased generation of reactive oxygen species and loss of mitochondrial membrane potential in tumor cells, providing a new approach for combined application of chemotherapy (CT) and chemodynamic therapy (CDT).

COLLOIDS AND SURFACES B-BIOINTERFACES (2021)

Article Nanoscience & Nanotechnology

Liposome-Coated Arsenic-Manganese Complex for Magnetic Resonance Imaging-Guided Synergistic Therapy Against Carcinoma

Zhexiu Jin et al.

Summary: LP@MnAsx, a liposome-coated arsenic-manganese complex, showed enhanced cellular uptake and tumor-killing efficiency in vitro experiments. In vivo studies demonstrated significantly improved tumor-specific distribution of arsenic, prolonged systemic circulation, and increased accumulation at the tumor site. This nanodelivery system can improve the non-specific distribution of NaAsO2 in vivo, expanding the research and application of arsenic trioxide against solid tumors.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

Article Polymer Science

PEGylated copper(II)-chelated polydopamine nanocomposites for photothermal-enhanced chemodynamic therapy against tumor cells

Qiuye Zhang et al.

Summary: A polydopamine-based nanoplatform was developed for photothermal-enhanced chemodynamic therapy, where the nanoparticles could react with GSH to generate Cu+ and produce hydroxyl radicals through a Fenton-like reaction, showing potential for tumor treatment.

JOURNAL OF APPLIED POLYMER SCIENCE (2021)

Article Chemistry, Physical

Synthesis of one-for-all type Cu5FeS4 nanocrystals with improved near infrared photothermal and Fenton effects for simultaneous imaging and therapy of tumor

Zhaojie Wang et al.

Summary: Three kinds of CuxFeySz nanomaterials were synthesized, with Cu5FeS4 exhibiting the best performance, including photothermal-enhanced Fenton effect and the ability to serve as an efficient MRI contrast agent for tumor elimination through chemodynamic effect.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2021)

Article Chemistry, Inorganic & Nuclear

MnO2 decorated ZIF-8@GOx for synergistic chemodynamic and starvation therapy of cancer

Jie Wang et al.

Summary: The study developed a nanoplatform by decorating MnO2 nanodots, which showed impressive performance in killing cancer cells by combining chemodynamic and cell starvation therapy. This method utilizes oxidative stress therapy and starvation therapy on tumor cells, providing a new prospect for cancer treatment.

JOURNAL OF SOLID STATE CHEMISTRY (2021)

Article Materials Science, Biomaterials

Ferrocene-functionalized hybrid hydrogel dressing with high-adhesion for combating biofilm

Yanling Peng et al.

Summary: This study successfully developed an antibacterial hydrogel dressing with high adhesion, which can effectively prevent bacterial infections and inhibit the formation of biofilms, providing a new opportunity for the treatment of clinical bacterial infections.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

Article Engineering, Biomedical

Biodegradable Copper-Based Nanoparticles Augmented Chemodynamic Therapy through Deep Penetration and Suppressing Antioxidant Activity in Tumors

Runxiao Zheng et al.

Summary: The CCMZ NPs are designed to enhance CDT efficacy by inhibiting HO-1 activity, depleting GSH, and converting hydrogen peroxide into hydroxyl radical to eliminate tumor cells efficiently.

ADVANCED HEALTHCARE MATERIALS (2021)

Article Engineering, Biomedical

Peroxidase-mimicking evodiamine/indocyanine green nanoliposomes for multimodal imaging-guided theranostics for oral squamous cell carcinoma

Zheng Wei et al.

Summary: Evodiamine and indocyanine green were integrated into a liposomal nanoplatform for noninvasive diagnostic imaging and combinatorial therapy against oral squamous cell carcinoma. The therapeutic liposomes showed significant inhibiting effect on tongue tumors through photodynamic therapy combined with chemodynamic chemotherapy in in vitro and in vivo experiments.

BIOACTIVE MATERIALS (2021)

Article Chemistry, Physical

Creating Structural Defects of Drug-Free Copper-Containing Layered Double Hydroxide Nanoparticles to Synergize Photothermal/Photodynamic/Chemodynamic Cancer Therapy

Luyao Sun et al.

Summary: A nanoplatform based on LDH nanoparticles has been developed for combined breast cancer therapy without traditional anticancer drugs, utilizing photothermal/photodynamic/chemodynamic therapy. By enhancing photothermal transduction and singlet-oxygen generation, the nanoplatform effectively inhibits tumor growth with low doses of Cu and ICG under mild laser irradiation.

SMALL STRUCTURES (2021)

Article Materials Science, Biomaterials

Endogenous reactive oxygen species burst induced and spatiotemporally controlled multiple drug release by traceable nanoparticles for enhancing antitumor efficacy

Ning Wang et al.

Summary: The synthesized pH/ROS dual-responsive multifunctional nanoparticles TLDCAG NPs show promising potential in tumor therapy, with abilities including multi-drug release and induction of tumor cell apoptosis.

BIOMATERIALS SCIENCE (2021)

Article Chemistry, Multidisciplinary

Co-biomembrane-coated Fe3O4/MnO2 multifunctional nanoparticles for targeted delivery and enhanced chemodynamic/photothermal/chemo therapy

Yingshu Guo et al.

Summary: The co-membrane system of MCF-7 breast cancer cell membrane and Escherichia coli membrane-coated Fe3O4/MnO2 multifunctional composite nanoparticles loaded with DOX was utilized for targeted drug delivery and biological imaging.

CHEMICAL COMMUNICATIONS (2021)

Article Chemistry, Multidisciplinary

A microenvironment-mediated Cu2O-MoS2 nanoplatform with enhanced Fenton-like reaction activity for tumor chemodynamic/photothermal therapy

Guligena Pidamaimaiti et al.

Summary: The study utilizes Cu2O-MoS2 nanomaterial to combine CDT and PTT, attacking tumor cells through enhanced Fenton-like reaction and photothermal effects, demonstrating promising therapeutic potential.

NEW JOURNAL OF CHEMISTRY (2021)

Article Materials Science, Biomaterials

Cu2-xSe/Bi2Se3@PEG Z-scheme heterostructure: a multimode bioimaging guided theranostic agent with enhanced photo/chemodynamic and photothermal therapy

Ying Wang et al.

Summary: This study successfully enhanced the production of reactive oxygen species for photodynamic therapy by preparing Cu2-xSe/Bi2Se3@PEG (CB3@PEG) nano-heterostructure, which exhibited great efficiency in both treatment and imaging capabilities.

BIOMATERIALS SCIENCE (2021)

Article Chemistry, Multidisciplinary

A multifunctional Fenton nanoagent for microenvironment-selective anti-biofilm and anti-inflammatory therapy

Yuqing Li et al.

Summary: FePS3 nanosheets show selective generation or elimination of ROS in different microenvironments, providing effective anti-biofilm and anti-inflammatory effects in the treatment of bacterial biofilm infections.

MATERIALS HORIZONS (2021)

Article Materials Science, Biomaterials

A dual-catalytic nanoreactor for synergistic chemodynamic-starvation therapy toward tumor metastasis suppression

Huiwen Zhang et al.

Summary: The study introduced a dual-catalytic nanoreactor for tumor metastasis suppression through synergistic chemodynamic therapy and starvation therapy, enhancing delivery efficiency and biological safety while effectively suppressing tumor metastasis with minimal side effects.

BIOMATERIALS SCIENCE (2021)

Article Materials Science, Biomaterials

Facile synthesis of Fe-baicalein nanoparticles for photothermal/chemodynamic therapy with accelerated FeIII/FeII conversion

Zhendong Liu et al.

Summary: Fe2+-baicalein-polyethylene glycol nanoparticles were synthesized using a wet chemical method at room temperature, with high photothermal conversion efficiency and effective antitumor efficacy achieved through synergistic photothermal/chemodynamic tumor therapy.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

Article Materials Science, Biomaterials

Biodegradable copper-metformin nanoscale coordination polymers for enhanced chemo/chemodynamic synergistic therapy by reducing oxygen consumption to promote H2O2 accumulation

Xiangyu Meng et al.

Summary: This study introduces a novel nanofiber drug carrier that inhibits tumor hypoxia and promotes H2O2 accumulation, achieving chemo/chemodynamic synergistic therapy and significantly suppressing tumor growth. The method also enhances efficacy by increasing ROS accumulation and cutting off energy supply.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

Article Materials Science, Biomaterials

Engineering Cu2-xS-conjugated upconverting nanocomposites for NIR-II light-induced enhanced chemodynamic/photothermal therapy of cancer

Kaimin Du et al.

Summary: The integration of chemodynamic therapy (CDT) and photothermal therapy (PTT) has led to the development of a novel multifunctional nanoplatform for enhanced anticancer treatment, providing potential for multi-modal imaging and therapy.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

Article Chemistry, Inorganic & Nuclear

NIR-triggered biodegradable MOF-coated upconversion nanoparticles for synergetic chemodynamic/photodynamic therapy with enhanced efficacy

Man Zou et al.

Summary: A new nano-composite UCZRF was designed to release photosensitizer and metal ions specifically in the tumor microenvironment, effectively enhancing the efficiency of ROS generation, and thus strengthening the anti-tumor effects of CDT and PDT.

INORGANIC CHEMISTRY FRONTIERS (2021)

Article Materials Science, Biomaterials

Coconut-shell-derived activated carbon for NIR photo-activated synergistic photothermal-chemodynamic cancer therapy

Gang Wu et al.

Summary: The study utilizes activated carbon nanoparticles (ANs) derived from coconut shell to exhibit peroxidase-mimic nanoenzyme activity for chemodynamic therapy (CDT) in cancer treatment. The PANs also show efficient photothermal conversion efficiency for photothermal therapy (PTT), with heating effect enhancing peroxidase-mimic activity, achieving a synergistic PTT-CDT therapeutic outcome. Additionally, Gd@PANs can be used for T1-magnetic resonance imaging (MRI) of tumors, integrating treatment and diagnosis.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

Article Chemistry, Multidisciplinary

A novel route to size-controlled MIL-53(Fe) metal-organic frameworks for combined chemodynamic therapy and chemotherapy for cancer

Anxia Li et al.

Summary: A new method was developed to synthesize controlled-size MIL-53(Fe) nanocrystals for cancer treatment by adding PVP as a surfactant to improve the growth process. This approach can produce uniform-shaped MIL-53(Fe) nanocrystals with the potential to improve drug release and treatment effects.

RSC ADVANCES (2021)

Article Chemistry, Multidisciplinary

CuO dot-decorated Cu@Gd2O3 core-shell hierarchical structure for Cu(i) self-supplying chemodynamic therapy in combination with MRI-guided photothermal synergistic therapy

Guilong Zhang et al.

Summary: The nanoplatform enhances mimic-peroxidase activity by self-supplying Cu(I), effectively inhibits tumor growth, and improves MRI contrast performance.

MATERIALS HORIZONS (2021)

Article Chemistry, Multidisciplinary

Manganese-doped gold core mesoporous silica particles as a nanoplatform for dual-modality imaging and chemo-chemodynamic combination osteosarcoma therapy

Zhou Sha et al.

Summary: This study presents an effective and easy strategy to construct a multifunctional nanoplatform combining bone targeted therapy and imaging diagnostics for osteosarcoma. The nanoplatform exhibited excellent tumor microenvironment responsive drug release efficiency and demonstrated outstanding combined therapy for killing cancer cells in vitro and suppressing tumor growth in vivo. CT and MR dual-modality imaging verified the effective accumulation of the nanoplatform at the tumor site, suggesting potential applications for efficient osteosarcoma therapy.

NANOSCALE (2021)

Article Chemistry, Multidisciplinary

A pH-responsive ultrathin Cu-based nanoplatform for specific photothermal and chemodynamic synergistic therapy

Tingting Hu et al.

Summary: This study has developed a novel tumor therapy nanoplatform by integrating acid-enhanced photothermal therapy and pH-responsive chemodynamic therapy, which almost eliminates tumor tissue in vivo with low-dose drug injection.

CHEMICAL SCIENCE (2021)

Article Chemistry, Multidisciplinary

Biodegradable FeWOx nanoparticles for CT/MR imaging-guided synergistic photothermal, photodynamic, and chemodynamic therapy

Yaru Cheng et al.

Summary: In this study, simple and biodegradable FeWOx ternary oxide nanoparticles were synthesized and surface-modified to possess both MRI/CT imaging capabilities and synergistic photothermal therapy/photodynamic therapy/chemodynamic therapy. The NPs showed excellent anticancer efficiency and precise imaging guidance in tumor microenvironment, making them a promising and versatile nanotheranostic platform.

NANOSCALE (2021)

Article Chemistry, Multidisciplinary

Near-infrared Zn-doped Cu2S quantum dots: an ultrasmall theranostic agent for tumor cell imaging and chemodynamic therapy

Shu-Lan Li et al.

Summary: This study reported a simple one-step synthesis method for ultrasmall Zn-doped Cu2S QDs with high CDT activity and fluorescence imaging capability. The QDs were able to specifically inhibit cancer cell growth and induce apoptosis via a Fenton-like reaction, showing potential as multi-functional theranostic agents.

NANOSCALE (2021)

Article Chemistry, Multidisciplinary

Mn-DNA coordination of nanoparticles for efficient chemodynamic therapy

Li Lin et al.

Summary: This nanoparticle utilizes high-molecular-weight DNA as a carrier to efficiently deliver and release Mn2+ in cancer cells, resulting in high toxicity through a Fenton-like reaction.

CHEMICAL COMMUNICATIONS (2021)

Article Materials Science, Biomaterials

Fenton-like reaction, glutathione reduction, and photothermal ablation-built-in hydrogels crosslinked by cupric sulfate for loco-regional cancer therapy

Sungyun Kim et al.

Summary: A crosslinked hydrogel system combining Fenton-like reaction and photothermal therapy was developed for loco-regional cancer therapy. Copper sulfate was used for crosslinking via metal-catechol coordination and covalent bonding of catechol group. The hydrogel structure incorporating copper can generate hydroxyl radicals and reduce intracellular glutathione levels, effectively enhancing ROS-initiated CDT efficiency for cancer treatment.

BIOMATERIALS SCIENCE (2021)

Article Materials Science, Biomaterials

One-for-all intelligent core-shell nanoparticles for tumor-specific photothermal-chemodynamic synergistic therapy

Hongshuai Wu et al.

Summary: Reasonable management of an all-in-one nanoplatform can lead to better cancer therapy. By integrating photothermal therapy and chemodynamic therapy, the intelligent core-shell nanoparticles demonstrate excellent synergistic antitumor efficiency with favorable biosafety. This innovative approach provides a new avenue for on-demand tumor-specific therapy.

BIOMATERIALS SCIENCE (2021)

Article Chemistry, Inorganic & Nuclear

Full-spectrum responsive WO3-x@HA nanotheranostics for NIR-II photoacoustic imaging-guided PTT/PDT/CDT synergistic therapy

Yanwen Ding et al.

Summary: A multifunctional WO3-based nanotheranostic with full-spectrum responsiveness was developed for synergistic therapy involving NIR-II photoacoustic imaging-guided photothermal, photodynamic, and chemodynamic therapies. By forming oxygen vacancies in WO3, the nanotheranostic exhibited enhanced therapeutic properties, including excellent photothermal conversion, reactive oxygen species production, and Fenton-like reaction capabilities, under NIR-II activation. In vitro and in vivo studies confirmed the potential of WO3-x@HA for precise theranostics in tumor-targeted PTT/PDT/CDT under real-time NIR-II PA imaging guidance.

INORGANIC CHEMISTRY FRONTIERS (2021)

Article Materials Science, Biomaterials

Chemodynamic/photothermal synergistic therapy based on Ce-doped Cu-Al layered double hydroxides

Zhengdi Wang et al.

Summary: This study designed Ce-doped Cu-Al layered double hydroxide (CAC-LDH) nanosheets loaded with indocyanine green (ICG) as a Fenton-catalyst and photothermal agent for synergistic chemodynamic therapy (CDT) and photothermal therapy (PTT) in cancer treatment. The results demonstrated the potential of ICG/CAC-LDH as an integrated agent for dual-modal imaging and synergistic CDT/PTT.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

Article Nanoscience & Nanotechnology

Supra-Carbon Dots Formed by Fe3+-Driven Assembly for Enhanced Tumor-Specific Photo-Mediated and Chemodynamic Synergistic Therapy

Qiao Chen et al.

Summary: A multifunctional cancer theranostic nanoplatform was developed through Fe3+-driven assembly of photosensitizer-decorated red emissive carbon dots, showing enhanced tumor accumulation and significantly improved anticancer performance by combining multiple therapeutic modalities. The ion-interference role of Fe3+-mediated chemodynamic therapy in anticancer nanomedicines was emphasized in this study.

ACS APPLIED BIO MATERIALS (2021)

Article Nanoscience & Nanotechnology

Melanin Nanoparticles Combined with CaO2 Nanoparticles for Image-Guided Tumor Microenvironment-Responsive Multimodal Therapy

Jia-Hui Yan et al.

Summary: By exploring the new characteristics of melanin nanoparticles, a multistimulus TME-responding nanoplatform was prepared, which improved the combined antitumor effect of CDT, PDT, and PTT. It also demonstrated the capability of multimethod imaging for monitoring the tumor treatment process.

ACS APPLIED NANO MATERIALS (2021)

Article Materials Science, Biomaterials

CuFeSe2-based thermo-responsive multifunctional nanomaterial initiated by a single NIR light for hypoxic cancer therapy

Juan Lu et al.

Summary: The study developed a multifunctional therapeutic system combining photothermal therapy, chemodynamic therapy, and hypoxic therapy, showing promising results in hypoxic tumor environments. Additionally, the nanoplatform also demonstrated superior diagnostic capabilities for CT and MRI, making it a potential candidate for simultaneous diagnosis and treatment in hypoxic cancer therapy.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

Article Medicine, Research & Experimental

Eradication of solid tumors by chemodynamic theranostics with H2O2-catalyzed hydroxyl radical burst

Nana Wang et al.

Summary: The study introduced a novel approach for personalized cancer treatment using the activatable theranostics PAsc/Fe@Cy7QB, which can specifically recognize and eradicate cancer cells efficiently. Results showed that this technology can release active substances within tumor cells for multimodal imaging and targeted therapy.

THERANOSTICS (2021)

Article Nanoscience & Nanotechnology

Erythrocyte Membrane-Encapsulated Glucose Oxidase and Manganese/Ferrite Nanocomposite as a Biomimetic All in One Nanoplatform for Cancer Therapy

Ruijiao Sun et al.

Summary: A biomimetic nanoplatform (MFG@RBCm) integrating multiple therapeutic modalities for tumor treatment was developed and characterized, showing great potential for synergistic therapy effects. The constructed nanoplatform demonstrated enhanced therapeutic outcomes in both in vitro and in vivo tests.

ACS APPLIED BIO MATERIALS (2021)

Article Chemistry, Multidisciplinary

An Activatable Nanoenzyme Reactor for Coenhanced Chemodynamic and Starving Therapy Against Tumor Hypoxia and Antioxidant Defense System

Zhihe Qing et al.

Summary: The article introduces a nanotechnology-based chemodynamic therapy (CDT) approach using a nanoenzyme reactor (NER) to increase oxygen levels, deplete antioxidants, and increase reactive oxygen species, in order to combat tumor hypoxia and antioxidant defense systems.

CCS CHEMISTRY (2021)

Article Chemistry, Multidisciplinary

Amorphous Fe-Based Nanoagents for Self-Enhanced Chemodynamic Therapy by Re-Establishing Tumor Acidosis

Xiaoyan Chen et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

Article Chemistry, Multidisciplinary

GSH-Depleted PtCu3 Nanocages for Chemodynamic- Enhanced Sonodynamic Cancer Therapy

Xiaoyan Zhong et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

Article Materials Science, Multidisciplinary

Biodegradable CoS2 nanoclusters for photothermal-enhanced chemodynamic therapy

Xianwen Wang et al.

APPLIED MATERIALS TODAY (2020)

Article Nanoscience & Nanotechnology

Engineering H2O2 Self-Supplying Nanotheranostic Platform for Targeted and Imaging-Guided Chemodynamic Therapy

Yajing Han et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

Article Nanoscience & Nanotechnology

Redox-Channeling Polydopamine-Ferrocene (PDA-Fc) Coating To Confer Context-Dependent and Photothermal Antimicrobial Activities

Jialin Song et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

Article Chemistry, Multidisciplinary

Co-Ferrocene MOF/Glucose Oxidase as Cascade Nanozyme for Effective Tumor Therapy

Chao Fang et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

Article Chemistry, Multidisciplinary

Biodegradable Nanoscale Coordination Polymers for Targeted Tumor Combination Therapy with Oxidative Stress Amplification

Jingjing Liu et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

Article Chemistry, Multidisciplinary

Enzyme-Mediated Tumor Starvation and Phototherapy Enhance Mild-Temperature Photothermal Therapy

Ge Gao et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

Article Chemistry, Multidisciplinary

Bioinspired Construction of a Nanozyme-Based H2O2 Homeostasis Disruptor for Intensive Chemodynamic Therapy

Yanjuan Sang et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

Review Nanoscience & Nanotechnology

Stimuli-activatable nanomedicines for chemodynamic therapy of cancer

Weiqi Wang et al.

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY (2020)

Article Nanoscience & Nanotechnology

Fe3O4 Mesocrystals with Distinctive Magnetothermal and Nanoenzyme Activity Enabling Self-Reinforcing Synergistic Cancer Therapy

Wenxian Du et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

Article Nanoscience & Nanotechnology

One Stone Two Birds: Zr-Fc Metal-Organic Framework Nanosheet for Synergistic Photothermal and Chemodynamic Cancer Therapy

Zheng Deng et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

Article Nanoscience & Nanotechnology

Integration of Fe3O4 with Bi2S3 for Multi-Modality Tumor Theranostics

Keyi Luo et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

Article Nanoscience & Nanotechnology

NIR-Driven Water Splitting H2 Production Nanoplatform for H2-Mediated Cascade-Amplifying Synergetic Cancer Therapy

Qi Wang et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

Article Chemistry, Multidisciplinary

Full-Process Radiosensitization Based on Nanoscale Metal-Organic Frameworks

Teng Gong et al.

ACS NANO (2020)

Article Chemistry, Multidisciplinary

Engineering a Therapy-Induced Immunogenic Cancer Cell Death Amplifier to Boost Systemic Tumor Elimination

Bei Li et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

Article Chemistry, Multidisciplinary

FeS@BSA Nanoclusters to Enable H2S-Amplified ROS-Based Therapy with MRI Guidance

Congkun Xie et al.

ADVANCED SCIENCE (2020)

Article Chemistry, Multidisciplinary

Photothermal-reinforced and glutathione-triggered in Situ cascaded nanocatalytic therapy

Peijing An et al.

JOURNAL OF CONTROLLED RELEASE (2020)

Article Chemistry, Multidisciplinary

Ultrafine Titanium Monoxide (TiO1+x) Nanorods for Enhanced Sonodynamic Therapy

Xianwen Wang et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

Article Engineering, Biomedical

Fe-Doped Polyoxometalate as Acid-Aggregated Nanoplatform for NIR-II Photothermal-Enhanced Chemodynamic Therapy

Yunhao Shi et al.

ADVANCED HEALTHCARE MATERIALS (2020)

Article Pharmacology & Pharmacy

Dihydroartemisinin-Loaded Magnetic Nanoparticles for Enhanced Chemodynamic Therapy

Shengdi Guo et al.

FRONTIERS IN PHARMACOLOGY (2020)

Article Chemistry, Multidisciplinary

Injectable Hydrogel for NIR-II Photo-Thermal Tumor Therapy and Dihydroartemisinin-Mediated Chemodynamic Therapy

Danyang Chen et al.

FRONTIERS IN CHEMISTRY (2020)

Article Chemistry, Multidisciplinary

H2O2-Responsive Nanogel for Enhancing Chemodynamic Therapy

Yuling Yang et al.

CHEMNANOMAT (2020)

Article Nanoscience & Nanotechnology

Endogenous Hydrogen Sulfide-Triggered MOF-Based Nanoenzyme for Synergic Cancer Therapy

Yite Li et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

Article Nanoscience & Nanotechnology

Photothermal Fenton Nanocatalysts for Synergetic Cancer Therapy in the Second Near-Infrared Window

Haitao Sun et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

Article Nanoscience & Nanotechnology

Photosensitizer-Doped and Plasma Membrane-Responsive Liposomes for Nuclear Drug Delivery and Multidrug Resistance Reversal

Ya-Xuan Zhu et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

Article Nanoscience & Nanotechnology

Near-Infrared-Activated Lysosome Pathway Death Induced by ROS Generated from Layered Double Hydroxide-Copper Sulfide Nanocomposites

Chen-Guang Liu et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

Article Chemistry, Multidisciplinary

A Graphdiyne Oxide-Based Iron Sponge with Photothermally Enhanced Tumor-Specific Fenton Chemistry

Huan Min et al.

ADVANCED MATERIALS (2020)

Article Chemistry, Multidisciplinary

MnOxNanospikes as Nanoadjuvants and Immunogenic Cell Death Drugs with Enhanced Antitumor Immunity and Antimetastatic Effect

Binbin Ding et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

Article Chemistry, Multidisciplinary

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