期刊
SMALL
卷 17, 期 50, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.202103993
关键词
antibacterial effect; heterojunction; phototherapy; Ti; C-3; (2) MXenes; tissue regeneration
类别
资金
- National Natural Science Foundation of China [81961160736, 81801848, 81870802]
- Sichuan Science and Technology Program [2021YJ0049, 2019YJ0141, 2019YFS0356]
- Chengdu International Science and Technology Cooperation Foundation [2017-GH02-00025-HZ, 2020-GH03-00005-HZ]
- State Key Laboratory of Polymer Materials Engineering [sklpme2019-2-05]
- Young Elite Scientist Sponsorship Program by CAST
- Youth Science and Technology Academic Leader Training Program of (Sichuan University)
- Sichuan University-Luzhou City Special Funding for Strategic Cooperation [2020CDLZ-5]
- Fundamental Research Funds for the Central Universities
- Sichuan University Postdoctoral Interdisciplinary Innovation
- Experimental Technology Project of Sichuan University [SCU201207]
A nano platform with multiple antibacterial functions was designed and fabricated in this study, which effectively eliminates bacteria and promotes cell migration using phototherapy, showing a positive influence on wound healing.
Phototherapy has recently emerged as a competent alternative for combating bacterial infection without antibiotic-resistance risk. However, owing to the bacterial endogenous antioxidative glutathione (GSH), the exogenous reactive oxygen species (ROS) generated by phototherapy can hardly behave desired antibacterial effect. To address the daunting issue, a quad-channel synergistic antibacterial nano-platform of Ti3C2 MXene/MoS2 (MM) 2D bio-heterojunctions (2D bio-HJs) are devised and fabricated, which possess photothermal, photodynamic, peroxidase-like (POD-like), and glutathione oxidase-like properties. Under near-infrared (NIR) laser exposure, the 2D bio-HJs both yield localized heating and raise extracellular ROS level, leading to bacterial inactivation. Synchronously, Mo4+ ions can easily invade into ruptured bacterial membrane, arouse intracellular ROS, and deplete intracellular GSH. Squeezed between the ROS hurricane from both internal and external sides, the bacteria are hugely slaughtered. After being further loaded with fibroblast growth factor-21 (FGF21), the 2D bio-HJs exhibit benign cytocompatibility and boost cell migration in vitro. Notably, the in vivo evaluations employing a mouse-infected wound model demonstrate the excellent photonic disinfection towards bacterial infection and accelerated wound healing. Overall, this work provides a powerful nano-platform for the effective regeneration of bacteria-invaded cutaneous tissue using 2D bio-HJs.
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