4.6 Article

Heparin Binding Protein for the Early Diagnosis and Prognosis of Sepsis in the Emergency Department: The Prompt Multicenter Study

期刊

SHOCK
卷 57, 期 4, 页码 518-525

出版社

LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/SHK.0000000000001900

关键词

Biomarker; heparin binding protein; outcome; procalcitonin; sepsis

资金

  1. InflaRx GmbH
  2. MSD Greece
  3. Angelini Italy
  4. AbbVie
  5. Abbott
  6. bio-Merieux Inc
  7. XBiotech Inc.
  8. FrameWork 7 program HemoSpec
  9. (National and Kapodistrian University of Athens)
  10. Horizon2020 Marie-Curie Project European Sepsis Academy
  11. Horizon 2020 European Grant ImmunoSep
  12. Hellenic Institute for the Study of Sepsis
  13. Axis Shield, UK
  14. JoinStar Biomedical, China

向作者/读者索取更多资源

The study discovered that HBP can serve as a tool for early diagnosis of sepsis and risk of early death in emergency department patients, demonstrating its potential value in clinical practice.
Background: The validation of new biomarkers for the diagnosis and risk stratification of patients with sepsis at an early point is essential for successful treatment. Recent publications prompted us to investigate of heparin binding protein (HBP) for the emergency department (ED) admissions. Materials and Methods: In this multicenter, cross-sectional study, HBP and procalcitonin (PCT) were measured within the first hour upon admission to the ED in plasma samples of 371 patients with signs of infection. Patients were classified into non-sepsis and sepsis by the Sepsis-3 definitions and were followed up for outcome. Results: HBP was significantly higher in patients with sepsis and was positively correlated to PCT and C-reactive protein, absolute neutrophil and monocyte counts, creatinine, bilirubin and lactate. Sensitivity, specificity, positive predictive value, and negative predictive value of HBP more than 19.8 ng/mL for the diagnosis of sepsis was 66.3%, 44.9%, 49.3%, and 62.2%, respectively; and for prediction of early death was 100%, 41.0%, 4.5%, and 100%, respectively. Single HBP and PCT could not predict 28-day mortality; this was performed with sensitivity, specificity, positive predictive value, and negative predictive value 44.8%, 81.8%, 17.3%, and 94.6% when used in combination. Conclusion: Admission HBP can be used as a tool for the early diagnosis of sepsis and for the risk of early death in the ED.

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