期刊
SENSORS AND ACTUATORS B-CHEMICAL
卷 359, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2022.131613
关键词
Heparin Sesnor; Porphyrin based probe; Colorimetry; Protamine detection; Fluorescence
资金
- Lady Tata Memorial Trust
- Amity Institute of Biotechnology, Amity University, Mumbai
- Sunandan Divatia School of Science, NMIMS
In this study, a tetracationic porphyrin based probe was developed for the detection of Heparin in 100% serum matrix with a clinically relevant LOD and high selectivity. The probe also showed potential for detecting Protamine.
Sensing Heparin in 100% serum matrix is a challenging task and is rarely reported in literature. Herein, we present a tetracationic porphyrin based probe that detects Heparin in 100% serum matrix, both, colorimetrically and fluommetrically, with a clinically relevant LOD. The probe also shows high selectivity towards Heparin when compared with its structurally related analogs, chondroitin sulfate and hyalumnic acid along with other relevant analytes. The porphyrin probe-Heparin complex could also be used for the detection of Protamine, which is the only clinically approved antitoxin for Heparin overdose. The easy commercial availability of the probe coupled with its other desirable attributes is expected to significantly improve its prospect in Heparin sensor applications and Heparin related bio-chemical research.
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