期刊
SENSORS AND ACTUATORS B-CHEMICAL
卷 348, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2021.130708
关键词
Molecular diagnosis; Point-of-care testing; Biosensing
资金
- Key Program of Natural Science Foundation of Shenzhen [JCYJ20200109113410174]
- Shenzhen Science and Technology Program [KQTD20170810105439418]
- National Natural Science Foundation of China [81973280, 21890742]
- Guangdong Province Covid-19 Pandemic Control Research Fund [2020KZDZX1223]
The molecular diagnosis has attracted more attention in infectious disease screening with successful understanding of the human genome, especially in light of the recent COVID-19 outbreak. Point-of-care testing (POCT) can expand the application of molecular diagnosis due to its rapid reply, low cost, and ability to work in decentralized environments, which has led many researchers and commercial institutions to focus on POCT-based biosensing for molecular diagnosis.
Molecular diagnosis, which plays a major role in infectious disease screening with successful understanding of the human genome, has attracted more attention because of the outbreak of COVID-19 recently. Since point-ofcare testing (POCT) can expand the application of molecular diagnosis with the benefit of rapid reply, low cost, and working in decentralized environments, many researchers and commercial institutions have dedicated tremendous effort and enthusiasm to POCT-based biosensing for molecular diagnosis. In this review, we firstly summarize the state-of-the-art techniques and the construction of biosensing systems for POC molecular diagnosis. Then, the application scenarios of POCT-based biosensing for molecular diagnosis were also reviewed. Finally, several challenges and perspectives of POC biosensing for molecular diagnosis are discussed. This review is expected to help researchers deepen comprehension and make progresses in POCT-based biosensing field for molecular diagnosis applications.
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