期刊
SENSORS AND ACTUATORS B-CHEMICAL
卷 350, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2021.130902
关键词
Fluorescence sensor; Multiplex chroma-response; Visual detection; Norfloxacin
资金
- National Natural Science Foundation of China [21876175]
- Key Research and Development Program of Anhui Province [202004d07020013]
- PostdoctorResearch Program of Anhui Province [E04GEGCF]
A novel fluorescent sensing platform was developed for rapid and sensitive detection of residual antibiotics, which exhibited a unique color response to NFX with high sensitivity and rapid response time. The platform has great potential for on-site and quantitative analysis of NFX, providing an effective pathway for rapid visual antibiotics detection.
Quinolone antibiotics such as norfloxacin (NFX) are widely used in human infection treatment. Oblivious intake antibiotics residues through water and food can exacerbate the pathogenesis of antibiotic-resistant bacterial. Therefore, it is pressing to develop applicable method for rapid and sensitive detection of residual antibiotics. Herein, we developed a novel multiplex chroma-response based fluorescent sensing platform for ultra-rapid and sensitive detection of NFX, where red-emitting CdTe quantum dots (QDs) employed as the internal reference and terbium ions (Tb3+) chelated onto the surface of QDs as the sensing unit. With the concentration of NFX increasing, the sensing platform provides a consecutive fluorescence color variation from red to yellow. The Tb/ CdTe QDs probe exhibits an extraordinary limit of detection (LOD) of 6.03 nM and completes the response within 2 s, enabling the visual dosage-sensitive and rapid detection of NFX. Additionally, the ratiometric fluorescent probe applied for visual and quantitative detection of NFX combined with smartphone color recognizer. The excellent sensitivity and selectivity as well as fast response speed mean the sensing platform has great potential application in on-site and quantitative NFX analysis, which provide an effective pathway for rapid visual antibiotics detection.
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