4.2 Review

Respiratory Syncytial Virus

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Incidence of Respiratory Syncytial Virus Infection Among Hospitalized Adults, 2017-2020

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Summary: This large prospective study found a high burden of RSV hospitalization in adults, particularly among older patients and those with cardiac conditions. These data highlight the need for effective RSV vaccines.

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The Future of Respiratory Syncytial Virus Disease Prevention and Treatment

Joseph B. Domachowske et al.

Summary: RSV is a major cause of respiratory tract infections in infants, young children, and older or immunocompromised adults, with current treatment primarily supportive. Palivizumab is the only licensed immunoprophylaxis for RSV disease in specific high-risk pediatric populations, but challenges such as cost and changing policy exist. New antiviral treatments for RSV are in early development stages, with promising long-acting monoclonal antibodies showing potential in early clinical trials.

INFECTIOUS DISEASES AND THERAPY (2021)

Article Respiratory System

Burden of respiratory syncytial virus infection in community-dwelling older adults in Europe (RESCEU): an international prospective cohort study

Koos Korsten et al.

Summary: This European study found that RSV infection is prevalent among community-dwelling older adults, but rarely causes severe disease. Patients with PCR-confirmed RSV ARTI had an average symptom duration of 19 days, with a doctor visit rate of 31%.

EUROPEAN RESPIRATORY JOURNAL (2021)

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Prevalent levels of RSV serum neutralizing antibodies in healthy adults outside the RSV-season

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Epidemiology and outcomes of hospitalized adults with respiratory syncytial virus: A 6-year retrospective study

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Review Medicine, General & Internal

Respiratory syncytial virus infection in adults

Hannah H. Nam et al.

BMJ-BRITISH MEDICAL JOURNAL (2019)

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Viral Load Dynamics and Clinical Disease Severity in Infants With Respiratory Syncytial Virus Infection

Cristina Garcia-Maurino et al.

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Review Infectious Diseases

Human respiratory syncytial virus: pathogenesis, immune responses, and current vaccine approaches

Sara A. Taleb et al.

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES (2018)

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Respiratory Syncytial Virus and Associations With Cardiovascular Disease in Adults

Kelsey S. Ivey et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2018)

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Down Syndrome and the Risk of Severe RSV Infection: A Meta-analysis

Andrea A. Beckhaus et al.

PEDIATRICS (2018)

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Respiratory Syncytial Virus: Infection, Detection, and New Options for Prevention and Treatment

Cameron Griffiths et al.

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Genomic Loads and Genotypes of Respiratory Syncytial Virus: Viral Factors during Lower Respiratory Tract Infection in Chilean Hospitalized Infants

Yazmin Espinosa et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

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ICTV Virus Taxonomy Profile: Pneumoviridae

Bert Rima et al.

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Vaccine development for respiratory syncytial virus

Barney S. Graham

CURRENT OPINION IN VIROLOGY (2017)

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The importance of RSV F protein conformation in VLPs in stimulation of neutralizing antibody titers in mice previously infected with RSV

Lori M. Cullen et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2017)

Article Emergency Medicine

RSV in adult ED patients: Do emergency providers consider RSV as an admission diagnosis?

William Binder et al.

AMERICAN JOURNAL OF EMERGENCY MEDICINE (2017)

Article Respiratory System

Respiratory Syncytial Virus Infection An Illness for All Ages

Edward E. Walsh

CLINICS IN CHEST MEDICINE (2017)

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Taxonomy of the order Mononegavirales: update 2016

Claudio L. Afonso et al.

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Aerosolized ribavirin: the most expensive drug for pneumonia

R. F. Chemaly et al.

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Masks for prevention of respiratory viruses on the BMT unit: results of a quality initiative

Kelsey A. Sokol et al.

TRANSPLANT INFECTIOUS DISEASE (2016)

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Impaired Antibody-mediated Protection and Defective IgA B-Cell Memory in Experimental Infection of Adults with Respiratory Syncytial Virus

Maximillian S. Habibi et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2015)

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Novel antigens for RSV vaccines

Barney S. Graham et al.

CURRENT OPINION IN IMMUNOLOGY (2015)

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Respiratory Syncytial Virus Infection in Older Adults: An Under-Recognized Problem

Angela R. Branche et al.

DRUGS & AGING (2015)

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Performance Characteristics of Xpert Flu/RSV XC Assay

Elena B. Popowitch et al.

JOURNAL OF CLINICAL MICROBIOLOGY (2015)

Article Virology

Does virus-bacteria coinfection increase the clinical severity of acute respiratory infection?

Guilherme A. C. Damasio et al.

JOURNAL OF MEDICAL VIROLOGY (2015)

Article Medicine, General & Internal

Activity of Oral ALS-008176 in a Respiratory Syncytial Virus Challenge Study

John P. DeVincenzo et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

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Community-Acquired Pneumonia Requiring Hospitalization among US Adults

S. Jain et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Article Cell Biology

Efficacy of a virus-vectored vaccine against human and bovine respiratory syncytial virus infections

Geraldine Taylor et al.

SCIENCE TRANSLATIONAL MEDICINE (2015)

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Respiratory syncytial virus- and human metapneumovirus-associated emergency department and hospital burden in adults

Kyle Widmer et al.

INFLUENZA AND OTHER RESPIRATORY VIRUSES (2014)

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Effectiveness of maternal pertussis vaccination in England: an observational study

Gayatri Amirthalingam et al.

LANCET (2014)

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Genetic Vaccine for Respiratory Syncytial Virus Provides Protection Without Disease Potentiation

Teresa R. Johnson et al.

MOLECULAR THERAPY (2014)

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Risk Factors for Respiratory Syncytial Virus Illness Among Patients with Chronic Obstructive Pulmonary Disease

Jyotsna Mehta et al.

COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (2013)

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Vaccines in Pregnant Women and Research Initiatives

C. Mary Healy

CLINICAL OBSTETRICS AND GYNECOLOGY (2012)

Article Multidisciplinary Sciences

Nonviral delivery of self-amplifying RNA vaccines

Andrew J. Geall et al.

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Article Infectious Diseases

Guidelines for the management of adult lower respiratory tract infections - Full version

M. Woodhead et al.

CLINICAL MICROBIOLOGY AND INFECTION (2011)

Review Biotechnology & Applied Microbiology

A review of palivizumab and emerging therapies for respiratory syncytial virus

Kristin A. Shadman et al.

EXPERT OPINION ON BIOLOGICAL THERAPY (2011)

Review Critical Care Medicine

Respiratory Viral Infections in Hematopoietic Stem Cell and Solid Organ Transplant Recipients

S. Samuel Weigt et al.

SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE (2011)

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Respiratory Viruses in Adults With Community-Acquired Pneumonia

David Lieberman et al.

Article Biophysics

Viral disease prevention after hematopoietic cell transplantation

J. Zaia et al.

BONE MARROW TRANSPLANTATION (2009)

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Effectiveness of maternal influenza immunization in mothers and infants

K. Zaman et al.

NEW ENGLAND JOURNAL OF MEDICINE (2008)

Article Immunology

Respiratory syncytial virus and influenza virus infections - Observations from tissues of fatal infant cases

Timothy P. Welliver et al.

PEDIATRIC INFECTIOUS DISEASE JOURNAL (2008)

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Influenza- and respiratory syncytial virus-associated mortality and hospitalisations

A. G. S. C. Jansen et al.

EUROPEAN RESPIRATORY JOURNAL (2007)

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Serum antibody decay in adults following natural respiratory syncytial virus infection

Ann R. Falsey et al.

JOURNAL OF MEDICAL VIROLOGY (2006)

Article Pediatrics

Epidemiology and clinical characteristics of respiratory syncytial virus infections in Jordan

Rani Al-Toum et al.

JOURNAL OF TROPICAL PEDIATRICS (2006)

Article Respiratory System

A single-season prospective study of respiratory viral infections in lung transplant recipients

A. P. Milstone et al.

EUROPEAN RESPIRATORY JOURNAL (2006)

Review Respiratory System

Guidelines for the management of adult lower respiratory tract infections

M Woodhead et al.

EUROPEAN RESPIRATORY JOURNAL (2005)

Article Medicine, General & Internal

Respiratory syncytial virus infection in elderly and high-risk adults

AR Falsey et al.

NEW ENGLAND JOURNAL OF MEDICINE (2005)

Review Cell Biology

The structural biology of type I viral membrane fusion

PM Colman et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2003)

Article Medicine, General & Internal

Mortality associated with influenza and respiratory syncytial virus in the United States

WW Thompson et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2003)

Article Immunology

Correlation between respiratory syncytial virus genotype and severity of illness

RA Martinello et al.

JOURNAL OF INFECTIOUS DISEASES (2002)

Review Medicine, General & Internal

Medical progress - Respiratory syncytial virus and parainfluenza virus.

CB Hall

NEW ENGLAND JOURNAL OF MEDICINE (2001)