4.3 Review

Radiomicrosphere Dosimetry: Principles and Current State of the Art

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Summary: This study established recommendations for the optimisation of selective internal radiation therapy (SIRT) with yttrium-90 (Y-90)-resin microspheres, based on expert panel discussions and survey responses from leading experts in the field. The recommendations cover various aspects of SIRT, including activity prescription, post-treatment dosimetry, and imaging for treatment verification. It is recommended that a multidisciplinary team define treatment strategy and therapeutic intent, and that a personalised approach using dosimetry be adopted for activity prescription. Additionally, post-SIRT imaging and dosimetry are strongly recommended for treatment verification and assessment.

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Personalised versus standard dosimetry approach of selective internal radiation therapy in patients with locally advanced hepatocellular carcinoma (DOSISPHERE-01): a randomised, multicentre, open-label phase 2 trial

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Individualised dosimetry and safety of SIRT for intrahepatic cholangiocarcinoma

Kathy P. Willowson et al.

Summary: ICC lesions exhibit a dose-response trend similar to mCRC, however, full metabolic response is rare despite high lesion doses. The coefficient of variation of lesion dose may significantly impact response, with EUD correlating more closely with metabolic response compared to D-avg. SIRT in primary liver malignancy is safe in terms of not inducing clinically significant decline in liver function, and low baseline uptake rate is not predictive of a reduction in function post-SIRT.

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Mina Jamre et al.

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90Y radioembolization dosimetry using a simple semi-quantitative method in intrahepatic cholangiocarcinoma: Glass versus resin microspheres

Nariman Nezami et al.

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Elena Gallio et al.

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Seza A. Gulec

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Kernel Based Dosimetry for 90Y Microsphere Liver Therapy Using 90Y Bremsstrahlung SPECT/CT

J. Mikell et al.

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Mohammed Goryawala et al.

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Sherry C. Ng et al.

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Mohammed Goryawala et al.

IEEE TRANSACTIONS ON INFORMATION TECHNOLOGY IN BIOMEDICINE (2012)

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Ruchir Bhatt et al.

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Computer Modeling of Controlled Microsphere Release and Targeting in a Representative Hepatic Artery System

Christopher A. Basciano et al.

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J. F. Fowler

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Radioembolisation with 90Y-microspheres: dosimetric and radiobiological investigation for multi-cycle treatment

Marta Cremonesi et al.

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Radiation dose limits and liver toxicities resulting from multiple yttrium-90 radioembolization treatments for hepatocellular carcinoma

Joseph Y. Young et al.

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Michael Stabin

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Resin 90Y-microsphere brachytherapy for unresectable colorectal liver metastases:: Modern USA experience

Andrew S. Kennedy et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2006)

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Radioembolization with (90)Yttrium microspheres: A state-of-the-art brachytherapy treatment for primary and secondary liver malignancies - Part 2: Special topics

Riad Salem et al.

JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY (2006)

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Radiation absorbed dose distribution in a patient treated with yttrium-90 microspheres for hepatocellular carcinoma

M Sarfaraz et al.

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Pathologic response and microdosimetry of 90Y microspheres in man:: Review of four explanted whole livers

AS Kennedy et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2004)

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Physical aspects of yttrium-90 microsphere therapy for nonresectable hepatic tumors

M Sarfaraz et al.

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