期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 130, 期 -, 页码 90-97出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2021.10.013
关键词
Nuclear envelope; Lipid homeostasis; Nuclear size; Nuclear morphology; Size control; Nuclear remodelling; Nuclear division
资金
- European Molecular Biology Organisation (EMBO, Heidelberg, Germany) LongTerm Fellowship
- European Molecular Biology Laboratory (EMBL, Heidelberg,Germany)
This review discusses the cellular properties and processes that contribute to nuclear size and shape control, providing examples from across eukaryotes. It also outlines the physiological roles of specific nuclear morphologies and the disease pathologies associated with aberrant nuclear morphology.
The nucleus displays a wide range of sizes and shapes in different species and cell types, yet its size scaling and many of the key structural constituents that determine its shape are highly conserved. In this review, we discuss the cellular properties and processes that contribute to nuclear size and shape control, drawing examples from across eukaryotes and highlighting conserved themes and pathways. We then outline physiological roles that have been uncovered for specific nuclear morphologies and disease pathologies associated with aberrant nuclear morphology. We argue that a comparative approach, assessing and integrating observations from different systems, will be a powerful way to help us address the open questions surrounding functional roles of nuclear size and shape in cell physiology.
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