4.6 Review

Microtubule and auditory function-an underestimated connection

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Neurosciences

Tubulin polyglutamylation, a regulator of microtubule functions, can cause neurodegeneration

Satish Bodakuntla et al.

Summary: Neurodegenerative diseases result in progressive neuronal dysfunction and death. Dysfunctions of the microtubule cytoskeleton are common features of these diseases. Posttranslational modifications of tubulin, such as polyglutamylation, may play a role in neuronal dysfunction and degeneration.

NEUROSCIENCE LETTERS (2021)

Article Multidisciplinary Sciences

Tubulin glycylation controls axonemal dynein activity, flagellar beat, and male fertility

Sudarshan Gadadhar et al.

Summary: This study demonstrates the importance of tubulin glycylation for controlled flagellar beating, directional sperm swimming, and male fertility by utilizing a mouse model lacking this modification. The lack of glycylation led to abnormal dynein arm conformations in sperm axonemes, resulting in subfertility in male mice due to aberrant beat patterns of sperm flagella.

SCIENCE (2021)

Article Multidisciplinary Sciences

The conformational cycle of prestin underlies outer-hair cell electromotility

Navid Bavi et al.

Summary: The study reveals the crucial role of prestin in mammalian hearing, its ability to sense voltage and transduce it into cellular movement, and its regulation by bound anions. Prestin exhibits unique and complex conformations in different binding states, influenced by the drug salicylate. Analysis shows how anion-dependent conformations affect structural rearrangements in the voltage sensor and conformational transitions at the protein-membrane interface.

NATURE (2021)

Article Multidisciplinary Sciences

Daple deficiency causes hearing loss in adult mice by inducing defects in cochlear stereocilia and apical microtubules

Yoshiyuki Ozono et al.

Summary: The study revealed the importance of Daple in hair bundle arrangement and its impact on hearing performance in adult mice. By regulating the distribution of apical microtubules, Daple plays a crucial role in high-frequency hearing.

SCIENTIFIC REPORTS (2021)

Article Cell Biology

Cochlear supporting cells require GAS2 for cytoskeletal architecture and hearing

Tingfang Chen et al.

Summary: In mammals, sound is detected by mechanosensory hair cells, with inner ear supporting cells playing a crucial role in transmitting sound energy through the cochlear partition. Mutations in the GAS2 gene can lead to hearing loss by disrupting the organization and stability of microtubule bundles in these supporting cells, affecting cochlear micromechanics. The bundling activity of GAS2 is essential for imparting mechanical properties to supporting cells for sound energy transmission in the cochlea.

DEVELOPMENTAL CELL (2021)

Article Medical Laboratory Technology

CYLD deficiency causes auditory neuropathy due to reduced neurite outgrowth

Song Yang et al.

Summary: By studying Cyld KO mice and nerve cell lines, it was found that CYLD protein might be associated with auditory neuropathy, and knocking down CYLD significantly reduces the length and proportion of neurites growing from nerve cells.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2021)

Article Cell Biology

Dispensability of Tubulin Acetylation for 15-protofilament Microtubule Formation in the Mammalian Cochlea

Justine Renauld et al.

Summary: The development of mammalian hearing relies on the specialized epithelium known as the organ of Corti, which contains sensory cells and supporting cells with unique 15-protofilament microtubules. In mice, 15-protofilament microtubules appear in pillar cells between the second and fourth day after birth. Microtubule acetylation is not essential for their formation in mice, but is necessary for fine-tuning their diameter.

CELL STRUCTURE AND FUNCTION (2021)

Article Biochemistry & Molecular Biology

Differential Roles of Tubby Family Proteins in Ciliary Formation and Trafficking

Julie J. Hong et al.

Summary: TULP3 and TUB are able to rescue defective cilia formation and ciliary protein trafficking in TULP3 knockout cells, while TULP1 and TULP2 only provide partial rescue. TUB's IFT-A binding capacity is crucial for its role in cilia formation and protein trafficking, while its PIP2 binding capacity is important for proper cilia length and IFT140 localization. Chimeric TULP1 with TULP3's IFT-A binding domain fully rescues ciliary protein trafficking but not cilia formation.

MOLECULES AND CELLS (2021)

Review Biochemistry & Molecular Biology

Cellular functions of actin- and microtubule-associated septins

Elias T. Spiliotis et al.

Summary: Septins are key components of the cytoskeleton, interacting with actin filaments, microtubules, and membranes to regulate the organization and dynamics of the cytoskeletal networks essential for cellular morphogenesis. They play roles in cytokinesis, cell migration, and host defense against pathogens, with emerging functions at the interface of microtubules and membranes. Additionally, septins are involved in mitosis and meiosis, making them a unique module of cytoskeletal regulators with properties of actin-binding and microtubule-associated proteins.

CURRENT BIOLOGY (2021)

Article Multidisciplinary Sciences

TTC5 mediates autoregulation of tubulin via mRNA degradation

Zhewang Lin et al.

SCIENCE (2020)

Review Cell Biology

The tubulin code and its role in controlling microtubule properties and functions

Carsten Janke et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

Article Multidisciplinary Sciences

CAMSAP3 facilitates basal body polarity and the formation of the central pair of microtubules in motile cilia

Alan M. Robinson et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Multidisciplinary Sciences

Distinct roles of stereociliary links in the nonlinear sound processing and noise resistance of cochlear outer hair cells

Woongsu Han et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Multidisciplinary Sciences

Effects of α-tubulin acetylation on microtubule structure and stability

Lisa Eshun-Wilson et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Review Cell Biology

Microtubule-Asssociated Proteins: Structuring the Cytoskeleton

Satish Bodakuntla et al.

TRENDS IN CELL BIOLOGY (2019)

Article Biochemistry & Molecular Biology

Tau filaments in neurodegenerative diseases

Michel Goedert

FEBS LETTERS (2018)

Article Biochemistry & Molecular Biology

Loss of tubulin deglutamylase CCP1 causes infantile-onset neurodegeneration

Vandana Shashi et al.

EMBO JOURNAL (2018)

Article Biochemistry & Molecular Biology

Excessive tubulin polyglutamylation causes neurodegeneration and perturbs neuronal transport

Maria M. Magiera et al.

EMBO JOURNAL (2018)

Article Cell Biology

Tubulin acetylation protects long-lived microtubules against mechanical ageing

Didier Portran et al.

NATURE CELL BIOLOGY (2017)

Article Multidisciplinary Sciences

Spectrin βV adaptive mutations and changes in subcellular location correlate with emergence of hair cell electromotility in mammalians

Matteo Cortese et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Multidisciplinary Sciences

Daple coordinates organ-wide and cell-intrinsic polarity to pattern inner-ear hair bundles

Kimberly Siletti et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Multidisciplinary Sciences

Vasohibins/SVBP are tubulin carboxypeptidases (TCPs) that regulate neuron differentiation

Chrystelle Aillaud et al.

SCIENCE (2017)

Article Multidisciplinary Sciences

Vasohibins encode tubulin detyrosinating activity

Joppe Nieuwenhuis et al.

SCIENCE (2017)

Article Genetics & Heredity

Mutations in TUBB4B Cause a Distinctive Sensorineural Disease

Romain Luscan et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2017)

Article Developmental Biology

Septin7 regulates inner ear formation at an early developmental stage

Hiroko Torii et al.

DEVELOPMENTAL BIOLOGY (2016)

Article Cell Biology

Evidence for new C-terminally truncated variants of α- and β-tubulins

Chrystelle Aillaud et al.

MOLECULAR BIOLOGY OF THE CELL (2016)

Editorial Material Cell Biology

Auditory system: development, genetics, function, aging, and diseases

Bernd Fritzsch et al.

CELL AND TISSUE RESEARCH (2015)

Article Biochemistry & Molecular Biology

Molecular Basis for Age-Dependent Microtubule Acetylation by Tubulin Acetyltransferase

Agnieszka Szyk et al.

Review Cell Biology

The tubulin code: Molecular components, readout mechanisms, and functions

Carsten Janke

JOURNAL OF CELL BIOLOGY (2014)

Article Neurosciences

ACF7 Is a Hair-Bundle Antecedent, Positioned to Integrate Cuticular Plate Actin and Somatic Tubulin

Patrick J. Antonellis et al.

JOURNAL OF NEUROSCIENCE (2014)

Article Pharmacology & Pharmacy

Ototoxicity of paclitaxel in rat cochlear organotypic cultures

Yang Dong et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2014)

Article Cell Biology

Structural basis of tubulin tyrosination by tubulin tyrosine ligase

Andrea E. Prota et al.

JOURNAL OF CELL BIOLOGY (2013)

Article Biochemistry & Molecular Biology

Posttranslational Acetylation of α-Tubulin Constrains Protofilament Number in Native Microtubules

Juan G. Cueva et al.

CURRENT BIOLOGY (2012)

Article Biochemistry & Molecular Biology

Genetically Separable Functions of the MEC-17 Tubulin Acetyltransferase Affect Microtubule Organization

Irini Topalidou et al.

CURRENT BIOLOGY (2012)

Article Audiology & Speech-Language Pathology

Deiters cells tread a narrow path-The Deiters cells-basilar membrane junction-

Arya Parsa et al.

HEARING RESEARCH (2012)

Article Audiology & Speech-Language Pathology

Localization of septin proteins in the mouse cochlea

Atsuhiro Yoshida et al.

HEARING RESEARCH (2012)

Article Biochemistry & Molecular Biology

Cytosolic Carboxypeptidase 1 Is Involved in Processing α- and β-Tubulin

Iryna Berezniuk et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Review Cell Biology

Spectraplakins: Master orchestrators of cytoskeletal dynamics

Kathleen C. Suozzi et al.

JOURNAL OF CELL BIOLOGY (2012)

Article Multidisciplinary Sciences

Structure and Mechanics of Supporting Cells in the Guinea Pig Organ of Corti

Deborah E. Zetes et al.

PLOS ONE (2012)

Article Biochemistry & Molecular Biology

A Family of Protein-Deglutamylating Enzymes Associated with Neurodegeneration

Krzysztof Rogowski et al.

Article Biochemistry & Molecular Biology

Prestin Surface Expression and Activity Are Augmented by Interaction with MAP1S, a Microtubule-associated Protein

Jun-Ping Bai et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Multidisciplinary Sciences

MEC-17 is an α-tubulin acetyltransferase

Jyothi S. Akella et al.

NATURE (2010)

Article Multidisciplinary Sciences

The major α-tubulin K40 acetyltransferase αTAT1 promotes rapid ciliogenesis and efficient mechanosensation

Toshinobu Shida et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Biophysics

Prestin's Anion Transport and Voltage-Sensing Capabilities Are Independent

Jun-Ping Bai et al.

BIOPHYSICAL JOURNAL (2009)

Article Biochemistry & Molecular Biology

Evolutionary Divergence of Enzymatic Mechanisms for Posttranslational Polyglycylation

Krzysztof Rogowski et al.

Article Cell Biology

TTLL3 Is a Tubulin Glycine Ligase that Regulates the Assembly of Cilia

Dorota Wloga et al.

DEVELOPMENTAL CELL (2009)

Article Cell Biology

Motor-dependent microtubule disassembly driven by tubulin tyrosination

Leticia Peris et al.

JOURNAL OF CELL BIOLOGY (2009)

Article Neurosciences

Auditory development in progressive motor neuronopathy mouse mutants

Stefan Volkenstein et al.

NEUROSCIENCE LETTERS (2009)

Article Cell Biology

Tubulin modifications and their cellular functions

Jennetta W. Hammond et al.

CURRENT OPINION IN CELL BIOLOGY (2008)

Article Cell Biology

Microtubule stabilization specifies initial neuronal polarization

Harald Witte et al.

JOURNAL OF CELL BIOLOGY (2008)

Article Neurosciences

Architecture of the mouse utricle: macular organization and hair bundle heights

A. Li et al.

JOURNAL OF NEUROPHYSIOLOGY (2008)

Review Cell Biology

Beyond polymer polarity: how the cytoskeleton builds a polarized cell

Rong Li et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)

Review Cell Biology

Organelle positioning and cell polarity

Michel Bornens

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)

Article Biochemistry & Molecular Biology

A targeted multienzyme mechanism for selective microtubule polyglutamylation

Juliette van Dijk et al.

MOLECULAR CELL (2007)

Review Developmental Biology

Shaping the mammalian auditory sensory organ by the planar cell polarity pathway

Michael Kelly et al.

INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY (2007)

Article Multidisciplinary Sciences

Tubulin polyglutamylase enzymes are members of the TTL domain protein family

C Janke et al.

SCIENCE (2005)

Review Genetics & Heredity

Genetic insights into the morphogenesis of inner ear hair cells

GI Frolenkov et al.

NATURE REVIEWS GENETICS (2004)

Article Neurosciences

Selective expression of β tubulin isotypes in gerbil vestibular sensory epithelia and neurons

B Perry et al.

JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY (2003)

Article Biochemistry & Molecular Biology

The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase

BJ North et al.

MOLECULAR CELL (2003)

Review Cell Biology

Post-translational modifications regulate microtubule function

S Westermann et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2003)

Article Genetics & Heredity

A missense mutation in Tbce causes progressive motor neuronopathy in mice

N Martin et al.

NATURE GENETICS (2002)

Article Neurosciences

Expression of the mouse Macf2 gene during inner ear development

EV Leonova et al.

MOLECULAR BRAIN RESEARCH (2002)

Article Multidisciplinary Sciences

HDAC6 is a microtubule-associated deacetylase

C Hubbert et al.

NATURE (2002)

Article Genetics & Heredity

Microtubule-associated protein 1A is a modifier of tubby hearing (moth1)

A Ikeda et al.

NATURE GENETICS (2002)

Article Otorhinolaryngology

Presence of autoantibodies in the sera of Meniere's disease

TJ Yoo et al.

ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY (2001)

Article Audiology & Speech-Language Pathology

Differential expression of β tubulin isotypes in the adult gerbil cochlea

R Hallworth et al.

HEARING RESEARCH (2000)

Article Multidisciplinary Sciences

Prestin is the motor protein of cochlear outer hair cells

J Zheng et al.

NATURE (2000)

Article Audiology & Speech-Language Pathology

Tubulin expression in the developing and adult gerbil organ of Corti

R Hallworth et al.

HEARING RESEARCH (2000)