期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 132, 期 -, 页码 38-50出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2021.12.010
关键词
Ubiquitin-like modifier; SUMO; Beta-grasp; Ubiquitin-interacting motif; Stress response; Post-translational modification; Ubl-code
资金
- European Union [765445]
- German Research Foundation [SFB1286/A9]
Stress is crucial for cellular and organismal evolution, but failure to adapt or restore homeostasis can lead to severe diseases or death. Protein post-translational modifications, especially SUMO modification, play a key role in the adaptive response to stress.
Stress is unavoidable and essential to cellular and organismal evolution and failure to adapt or restore homeostasis can lead to severe diseases or even death. At the cellular level, stress drives a plethora of molecular changes, of which variations in the profile of protein post-translational modifications plays a key role in mediating the adaptative response of the genome and proteome to stress. In this context, post-translational modification of proteins by ubiquitin-like modifiers, (Ubl), notably SUMO, is an essential stress response mechanism. In this review, aiming to draw universal concepts of the Ubls stress response, we will decipher how stress alters the expression level, activity, specificity and/or localization of the proteins involved in the conjugation pathways of the various type-I Ubls, and how this result in the modification of particular Ubl targets that will translate an adaptive physiological stress response and allow cells to restore homeostasis.
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