期刊
SEMINARS IN CANCER BIOLOGY
卷 86, 期 -, 页码 445-456出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2022.02.004
关键词
Hepatocellular carcinoma; Metabolism; Cancer; Lipidomics; Lipid
类别
资金
- A*STAR Biomedical Research Council
- A*STAR Use-Inspired Basic Research Award
- National Research Foundation Competitive Research Program Award
- Brain-Body Initiative Strategic Research Fund
- Open Fund-Young Individual Research Grant from the National Medical Research Council, Singapore
- A*STAR Research Attachment Program
- Singapore National Medical Research Council
Alterations in metabolic pathways, especially in lipid metabolism, are significant in hepatocellular carcinoma. Understanding the lipidomic landscape of HCC is crucial for elucidating the mechanisms of tumor initiation and progression and finding potential therapeutic strategies.
Alterations in metabolic pathways are a hallmark of cancer. A deeper understanding of the contribution of different metabolites to carcinogenesis is thus vitally important to elucidate mechanisms of tumor initiation and progression to inform therapeutic strategies. Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide and its altered metabolic landscape is beginning to unfold with the advancement of technol-ogies. In particular, characterization of the lipidome of human HCCs has accelerated, and together with biochemical analyses, are revealing recurrent patterns of alterations in glycerophospholipid, sphingolipid, cholesterol and bile acid metabolism. These widespread alterations encompass a myriad of lipid species with numerous roles affecting multiple hallmarks of cancer, including aberrant growth signaling, metastasis, evasion of cell death and immunosuppression. In this review, we summarize the current trends and findings of the altered lipidomic landscape of HCC and discuss their potential biological significance for hepatocarcinogenesis.
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