4.6 Article

Checkpoint: Inspecting the barriers in glioblastoma immunotherapies

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Oncology

Durvalumab, with or without tremelimumab, plus platinum-etoposide versus platinum-etoposide alone in first-line treatment of extensive-stage small-cell lung cancer (CASPIAN): updated results from a randomised, controlled, open-label, phase 3 trial

Jonathan W. Goldman et al.

Summary: The study showed that first-line treatment with durvalumab plus platinum-etoposide resulted in sustained improvement in overall survival, while the addition of tremelimumab to this combination did not significantly enhance efficacy. These findings support the use of durvalumab plus platinum-etoposide as a new standard of care for extensive-stage small-cell lung cancer.

LANCET ONCOLOGY (2021)

Article Immunology

Memory-like HCV-specific CD8+ T cells retain a molecular scar after cure of chronic HCV infection

Nina Hensel et al.

Summary: The study reveals a progenitor-progeny relationship between memory-like and terminally exhausted HCV-specific CD8(+) T cells via an intermediate subset. Following DAA therapy to eliminate chronic antigen stimulation, memory-like cells are maintained while terminally exhausted cells are lost, resulting in a memory polarization of the overall HCV-specific CD8(+) T cell response. However, an exhausted core signature of memory-like CD8(+) T cells is still detectable even after viral clearance.

NATURE IMMUNOLOGY (2021)

Review Oncology

Immunocompetent Mouse Models in the Search for Effective Immunotherapy in Glioblastoma

Roxanne Wouters et al.

Summary: Glioblastoma remains a highly aggressive brain tumor with limited treatment options, despite the advancements in preclinical immunotherapeutic approaches. The discrepancy between successful animal experiments and clinical trials may be attributed to the inability of current mouse models to fully replicate the complexity and heterogeneity of the disease. Understanding and combining different mouse models may be crucial in capturing the full spectrum of GBM for effective research and drug testing.

CANCERS (2021)

Review Oncology

Combination immunotherapy strategies for glioblastoma

Hok Yee Chan et al.

Summary: Despite various combination strategies involving ICB, current immunotherapies have limited efficacy in treating GBM. There is a discordance of survival outcomes between preclinical models and clinical trials, likely due to the heterogeneity of GBM in patients and other adaptive immune mechanisms. However, neoadjuvant ICB therapy in GBM has shown promising results in diversifying the TCR repertoire and increasing chemokine mRNA transcripts.

JOURNAL OF NEURO-ONCOLOGY (2021)

Article Multidisciplinary Sciences

Neoadjuvant anti-OX40 (MEDI6469) therapy in patients with head and neck squamous cell carcinoma activates and expands antigen-specific tumor-infiltrating T cells

Rebekka Duhen et al.

Summary: The study demonstrates that in patients with head and neck cancer, preoperative use of an OX40 antibody increases clonality, and enhances activation and proliferation of CD4+ and CD8+ T cells.

NATURE COMMUNICATIONS (2021)

Article Multidisciplinary Sciences

Cell-programmed nutrient partitioning in the tumour microenvironment

Bradley Reinfeld et al.

Summary: The study found that in the tumor microenvironment, different cell types have varying abilities to access and consume glucose and glutamine, with nutrient partitioning being programmed in a cell-intrinsic manner through mTORC1 signaling and the expression of genes related to glucose and glutamine metabolism.

NATURE (2021)

Article Immunology

Differentiation of exhausted CD8+ T cells after termination of chronic antigen stimulation stops short of achieving functional T cell memory

Pierre Tonnerre et al.

Summary: The study highlights the impact of T cell exhaustion on clearing chronic infections and malignant cells. Even after cure of HCV infection, exhausted T cells show durable exhaustion at functional, phenotypic, and transcriptional levels.

NATURE IMMUNOLOGY (2021)

Article Multidisciplinary Sciences

Synergistic immunotherapy of glioblastoma by dual targeting of IL-6 and CD40

Fan Yang et al.

Summary: This study demonstrates that IL-6 blockade, in combination with a CD40 agonist, overcomes macrophage-mediated immunosuppression and sensitizes glioblastoma to immune checkpoint blockade in preclinical models, providing promising opportunities for GBM and other solid tumors.

NATURE COMMUNICATIONS (2021)

Article Multidisciplinary Sciences

CCR2 inhibition reduces tumor myeloid cells and unmasks a checkpoint inhibitor effect to slow progression of resistant murine gliomas

Joseph A. Flores-Toro et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Biochemistry & Molecular Biology

Neoadjuvant nivolumab modifies the tumor immune microenvironment in resectable glioblastoma

Kurt A. Schalper et al.

NATURE MEDICINE (2019)

Article Biochemistry & Molecular Biology

Immune and genomic correlates of response to anti-PD-1 immunotherapy in glioblastoma

Junfei Zhao et al.

NATURE MEDICINE (2019)

Article Multidisciplinary Sciences

Blood-brain barrier permeable nano immunoconjugates induce local immune responses for glioma therapy

Anna Galstyan et al.

NATURE COMMUNICATIONS (2019)

Article Multidisciplinary Sciences

Differential control of human Treg and effector T cells in tumor immunity by Fc-engineered anti-CTLA-4 antibody

Danbee Ha et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Review Oncology

Current state of immunotherapy for glioblastoma

Michael Lim et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2018)

Article Gastroenterology & Hepatology

Tremelimumab in combination with ablation in patients with advanced hepatocellular carcinoma

Austin G. Duffy et al.

JOURNAL OF HEPATOLOGY (2017)

Article Oncology

Inhibition of arginase by CB-1158 blocks myeloid cell-mediated immune suppression in the tumor microenvironment

Susanne M. Steggerda et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2017)

Review Biochemistry & Molecular Biology

Understanding the Intersections between Metabolism and Cancer Biology

Matthew G. Vander Heiden et al.

Article Oncology

Anti-GITR therapy promotes immunity against malignant glioma in a murine model

Jason Miska et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2016)

Editorial Material Oncology

Successful Treatment of a Patient with Glioblastoma and a Germline POLE Mutation: Where Next?

Alexandra Snyder et al.

CANCER DISCOVERY (2016)

Article Medicine, General & Internal

Nivolumab plus Ipilimumab in Advanced Melanoma

Jedd D. Wolchok et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Article Multidisciplinary Sciences

An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

Christiane A. Opitz et al.

NATURE (2011)

Article Medicine, General & Internal

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

F. Stephen Hodi et al.

NEW ENGLAND JOURNAL OF MEDICINE (2010)

Review Immunology

The significance of OX40 and OX40L to T-cell biology and immune disease

Michael Croft et al.

IMMUNOLOGICAL REVIEWS (2009)

Article Clinical Neurology

Indoleamine 2,3-dioxygenase as a new target for malignant glioma therapy Laboratory investigation

Takeshi Miyazaki et al.

JOURNAL OF NEUROSURGERY (2009)

Article Hematology

OX40 costimulation turns off Foxp3+ tregs

Minh Diem Vu et al.

Article Immunology

Distinct robes of CTLA-4 and TGF-β in CD4+CD25+ regulatory T cell function

QZ Tang et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2004)

Article Immunology

Constitutive OX40/OX40 ligand interaction induces autoimmune-like diseases

K Murata et al.

JOURNAL OF IMMUNOLOGY (2002)

Article Multidisciplinary Sciences

Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade

Y Iwai et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Article Multidisciplinary Sciences

PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine

T Okazaki et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

Article Multidisciplinary Sciences

Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice

H Nishimura et al.

SCIENCE (2001)

Article Multidisciplinary Sciences

ICOS co-stimulatory receptor is essential for T-cell activation and function

C Dong et al.

NATURE (2001)

Article Multidisciplinary Sciences

ICOS is critical for CD40-mediated antibody class switching

AJ McAdam et al.

NATURE (2001)

Article Multidisciplinary Sciences

ICOS is essential for effective T-helper-cell responses

A Tafuri et al.

NATURE (2001)