4.5 Article

A noninvasive iRFP713 p53 reporter reveals dynamic p53 activity in response to irradiation and liver regeneration in vivo

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Summary: The p53 tumor suppressor protein, which activates proliferative arrest and cell death, is regulated by MDM2 protein in normal cells. Blocking the interaction between MDM2 protein and E2/ubiquitin complex to enhance p53 response to DNA damage suggests a promising avenue for therapeutic development.

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