期刊
SCIENCE SIGNALING
卷 14, 期 714, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/scisignal.abj0057
关键词
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资金
- European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant [800194]
- Swiss National Science Foundation [SNF 31003A_166663, 310030_192730, SNF 310030_189065]
- Swiss Multiple Sclerosis Society
- Swiss Heart Foundation
- Swiss National Science Foundation (SNF) [310030_192730, 310030_189065, 31003A_166663] Funding Source: Swiss National Science Foundation (SNF)
- Marie Curie Actions (MSCA) [800194] Funding Source: Marie Curie Actions (MSCA)
Coronin 1 protein plays a critical role in the survival of naive T cells in the periphery by maintaining the activity of PI3K delta and suppressing apoptosis. Furthermore, it functions independently of pMHC:TCR and IL-7 signaling, but is essential for peripheral T cell survival.
The control of T cell survival is crucial for defense against infectious pathogens or emerging cancers. Although the survival of peripheral naive T cells has been proposed to be controlled by interleukin-7 (IL-7) signaling and T cell receptor (TCR) activation by peptide-loaded major histocompatibility complexes (pMHC), the essential roles for these pathways in thymic output and T cell proliferation have complicated the analysis of their contributions to T cell survival. Here, we showed that the WD repeat-containing protein coronin 1, which is dispensable for thymic selection and output, promoted naive T cell survival in the periphery in a manner that was independent of TCR and IL-7 signaling. Coronin 1 was required for the maintenance of the basal activity of phosphoinositide 3-kinase delta (PI3K delta), thereby suppressing caspase 8-mediated apoptosis. These results therefore reveal a coronin 1-dependent PI3K delta pathway that is independent of pMHC:TCR and IL-7 signaling and essential for peripheral T cell survival.
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