期刊
SCIENCE CHINA-CHEMISTRY
卷 64, 期 12, 页码 2218-2229出版社
SCIENCE PRESS
DOI: 10.1007/s11426-021-1070-6
关键词
nanomotor; NIR-II photoacoustic imaging; ultrasound; sonodynamic therapy; gas therapy
资金
- National Natural Science Foundation of China [21874024, 22027805, 21804068]
- National Key R&D Program of China [2020YFA0210800]
- joint re-search projects of Health and Education Commission of Fujian Province [2019-WJ-20]
- Natural Science Foundation of Fujian Province [2020J02012]
Traditional contrast agents have limitations in penetrating deep into tumor tissues, while using micro/nanomotors as active theranostic agents can enhance PA/US imaging and enable precise therapy for large tumors.
Varieties of contrast agents have been developed for photoacoustic (PA) and ultrasound (US) imaging of cancers in vivo. However, access of traditional contrast agents into the sites of tumors has been principally through passive infiltration without any external force, preventing their deep penetration into the tissues of the tumors, and hindering the use of PA and US for deep tumor imaging. The concept of micro/nanomotors has been the focus of increasing attention as active theranostic agents due to their active movement in particular fluids, thereby conducting assigned tasks. Herein, US-propelled Janus mesoporous SiO2 partially coated gold nanorods (Au NR-mSiO(2)) were fabricated for deep tumor NIR-II PA imaging and synergistic sonodynamic-gas therapy. Following US irradiation, 2,2-azobis[2-(2-imidazolin-2-yl) propane] dihydrochloride (AIPH) loaded in mSiO(2) (Au NR-mSiO(2)/AIPH) generated N-2 microbubbles with high efficiency to achieve nanomotor drive. Due to the deep penetration of US, the nanomotors exhibited a capability to travel deep within sites of tumors, providing enhanced PA/US imaging inside the tumors. Furthermore, the nanomotor based cancer therapy was demonstrated through synergistic N-2 gas and sonodynamic therapy. The US-propelled nanomotors demonstrated a novel strategy for the simultaneous PA/US dual imaging deep within tumor tissues and precise therapy of large tumors.
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