期刊
SCIENCE
卷 374, 期 6574, 页码 1492-+出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.abh4272
关键词
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资金
- Canadian Institutes of Health Research
- National Institute of Mental Health (NIMH) [K99MH11284002]
- American Epilepsy Society (AES) Junior Investigator Award
- Stanford Epilepsy Training Grant - National Institute of Neurological Disorders and Stroke (NINDS) [5T32NS007280]
- Swiss National Science Foundation Postdoctoral Fellowship
- National Science Foundation [DGE-114747]
- Gates Millennium Scholarship
- Japan Society for the Promotion of Science (JSPS) Overseas Fellowship
- AES Postdoctoral Fellowship
- NINDS [K99NS117795]
- National Institute of Health (NIH) [1U19NS104590]
- NIMH [1R01MH124047, 1R01MH124867]
- Kavli Foundation
- NIH
- NSF
- NOMIS Foundations
- Gatsby
- Fresenius
- HHMI Gilliam Fellowship for Advanced Study
Research has identified neurons in the supramammillary nucleus (SuM) that are highly correlated with future locomotor speed and reliably drive locomotion. Specifically, Tac1-expressing neurons in the SuM were found to control the activity of speed-modulated hippocampal neurons. These findings suggest that the SuM not only regulates basic locomotor activity but also selectively shapes hippocampal neural activity in a way that may support spatial navigation.
Locomotor speed is a basic input used to calculate one's position, but where this signal comes from is unclear. We identified neurons in the supramammillary nucleus (SuM) of the rodent hypothalamus that were highly correlated with future locomotor speed and reliably drove locomotion when activated. Robust locomotion control was specifically identified in Tac1 (substance P)-expressing (SuM(Tac1+)) neurons, the activation of which selectively controlled the activity of speed-modulated hippocampal neurons. By contrast, Tac1-deficient (SuM(Tac1-)) cells weakly regulated locomotion but potently controlled the spike timing of hippocampal neurons and were sufficient to entrain local network oscillations. These findings emphasize that the SuM not only regulates basic locomotor activity but also selectively shapes hippocampal neural activity in a manner that may support spatial navigation.
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