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Article
Multidisciplinary Sciences
Jennifer M. Dan et al.
Summary: Different components of immune memory to SARS-CoV-2 exhibit distinct kinetics, with antibodies and spike-specific memory B cells remaining relatively stable over 6 months, while CD4(+) T cells and CD8(+) T cells declining with a half-life of 3 to 5 months after infection.
Article
Medicine, General & Internal
Jayakrishnan Unnikrishnan et al.
Summary: By estimating the true fraction of reported COVID-19 cases using delay-adjusted case fatality ratios, significant variations are observed among different states, which can be used to guide policy priorities for testing and analyze the effects of different quarantine measures.
Article
Multidisciplinary Sciences
Nicholas G. Davies et al.
Summary: A new variant of SARS-CoV-2 has emerged in England, with a higher reproduction number and potential for large resurgences of COVID-19 cases. Without stringent control measures, it is projected that COVID-19 hospitalizations and deaths in England for the first 6 months of 2021 will exceed those in 2020. The variant has spread globally and exhibited similar transmission increases in Denmark, Switzerland, and the United States.
Article
Medicine, General & Internal
Joel Hellewell et al.
Summary: The study used Bayesian statistical model to analyze PCR testing data of UK healthcare workers, finding that the detection probability peaked at 77% 4 days after infection but decreased to 50% by 10 days. Testing every other day was estimated to detect 57% of symptomatic cases before onset and 94% of asymptomatic cases within 7 days if results are returned promptly.
Article
Infectious Diseases
Manoj Murhekar et al.
Summary: The third serosurvey conducted in India between December 2020 and January 2021 revealed that nearly one in four individuals aged >10 years from the general population as well as healthcare workers had been exposed to SARS-CoV-2 by December 2020, with seroprevalence rates of 24.1% and 25.6% respectively.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Medicine, General & Internal
Christian Holm Hansen et al.
Summary: The study investigated the protection against SARS-CoV-2 reinfection, with results showing an 80.5% protection rate for individuals previously infected. Even in the population aged 65 years and older, the protection rate against reinfection reached 47.1%, with no significant differences observed by gender or time since infection.
Article
Medicine, General & Internal
Victoria Jane Hall et al.
Summary: This study investigated whether antibodies against SARS-CoV-2 were associated with a decreased risk of symptomatic and asymptomatic reinfection. It found that individuals with a previous history of SARS-CoV-2 infection had an 84% lower risk of reinfection, with a median protective effect lasting for 7 months following primary infection.
Article
Multidisciplinary Sciences
Nuno R. Faria et al.
Summary: A new variant of concern, P.1, with 17 mutations including three spike protein mutations associated with increased binding to human ACE2 receptors, emerged in Manaus, Brazil between November 2020 and January 2021. Molecular analysis suggests P.1 may be 1.7- to 2.4-fold more transmissible and that previous infection may provide 54 to 79% protection against P.1 infection compared to other lineages. Enhanced global genomic surveillance of such variants is crucial for pandemic response.
Article
Biology
Salwa Naushin et al.
Summary: The Council of Scientific and Industrial Research in India conducted a serosurvey in August and September 2020 to understand the spread of SARS-CoV2 and found that some individuals may be infected with the virus even without symptoms. Personal factors such as high-exposure work, use of public transport, non-smoking, non-vegetarian diet, and blood type B are associated with higher odds of seropositivity.
Review
Infectious Diseases
Soumik Purkayastha et al.
Summary: This study examined five epidemiological models to forecast and assess the course of the COVID-19 pandemic in India. Results showed that the SEIR-fansy and eSIR models had the lowest prediction errors for active case counts, while SAPHIRE and SEIR-fansy models performed better for cumulative case counts and death counts. The study also analyzed underreporting factors and uncertainty in projections from each model.
BMC INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Delphine Planas et al.
Summary: The SARS-CoV-2 B.1.617 Delta variant, first identified in India in 2020, has become dominant in some regions and is spreading to many countries. This variant shows resistance to certain monoclonal antibodies and antibodies in convalescent sera, as well as reduced neutralization by some COVID-19 vaccines. Administration of two doses of the vaccine is needed for a neutralizing response against the Delta variant.
Article
Multidisciplinary Sciences
James A. Hay et al.
Summary: Population distribution of viral loads changes during an epidemic, and Ct values from random samples can improve estimates of an epidemic's trajectory. Combining data from multiple samples enhances the precision and robustness of estimation. These methods can be applied to real-time estimates of epidemic trajectories for outbreak management and response.
Article
Virology
Aine O'Toole et al.
Summary: The global virus genomics community has responded unprecedentedly to the SARS-CoV-2 pandemic, leading to significant advances in 'real-time' generation and sharing of genomic data. The development of new analytical methods, such as pangolin, has been necessary to handle the rapid growth in virus genome data production. Pangolin has processed nearly two million virus genomes, aiding in SARS-CoV-2 genomic epidemiology and providing researchers with valuable information about the pandemic's transmission lineages.
Article
Multidisciplinary Sciences
Petra Mlcochova et al.
Summary: The B.1.617.2 (Delta) variant of SARS-CoV-2 has lower sensitivity to antibodies and higher replication efficiency compared to other lineages, which may contribute to its dominance and reduced vaccine effectiveness, highlighting the need for continued infection control measures post-vaccination.
Article
Medicine, General & Internal
Swapnil Mishra et al.
Summary: Since late March 2021, the percentage of non-B.1.1.7 variants has been increasing in London and other English regions, driven by a variety of lineages with immune escape. From mid-April, B.1.617.2 (WHO label Delta) spread rapidly, becoming the dominant variant in England by late May. The competition between variants and the rise of non-B.1.1.7 variants underscore the importance of diverse data sources in community surveillance for early detection of new variants.
Article
Biochemistry & Molecular Biology
Bui Quang Minh et al.
MOLECULAR BIOLOGY AND EVOLUTION
(2020)
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Multidisciplinary Sciences
Fan Wu et al.
Article
Microbiology
Andrew Rambaut et al.
NATURE MICROBIOLOGY
(2020)
Article
Medicine, General & Internal
Pedro M. Folegatti et al.
Article
Multidisciplinary Sciences
Seth Flaxman et al.
Article
Biology
Benny Borremans et al.
Article
Multidisciplinary Sciences
H. Juliette T. Unwin et al.
NATURE COMMUNICATIONS
(2020)
Article
Immunology
Manoj V. Murhekar et al.
INDIAN JOURNAL OF MEDICAL RESEARCH
(2020)
Article
Biochemical Research Methods
James Hadfield et al.
Article
Virology
Pavel Sagulenko et al.
Editorial Material
Infectious Diseases
Yuelong Shu et al.
