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Review Neurosciences

Neocortical Layer 1: An Elegant Solution to Top-Down and Bottom-Up Integration

Benjamin Schuman et al.

Summary: The brain relies on the ability of the neocortex to integrate sensory information with internal signals in order to make quick adjustments to behavior, with pyramidal cells in layer 1 playing a crucial role. Layer 1 serves as the primary input layer for top-down information, contributing to functions such as sensory perception, cross-modal integration, controlling states of consciousness, attention, and learning.

ANNUAL REVIEW OF NEUROSCIENCE, VOL 44, 2021 (2021)

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Article Neurosciences

Burst-dependent synaptic plasticity can coordinate learning in hierarchical circuits

Alexandre Payeur et al.

Summary: The authors propose a synaptic plasticity rule for pyramidal neurons based on postsynaptic bursting that captures experimental data and solves the credit assignment problem for deep networks. The study shows that regulating synaptic plasticity through high-frequency bursts of spikes can enable coordination of plasticity in hierarchical circuits. When paired with short-term synaptic dynamics and regenerative activity in the apical dendrites, this burst-dependent learning rule can solve challenging tasks requiring deep network architectures.

NATURE NEUROSCIENCE (2021)

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Article Multidisciplinary Sciences