Remote steric control for undirected meta-selective C-H activation of arenes

Regioselective functionalization of arenes remains a challenging problem in organic synthesis. Steric interactions are often used to block sites adjacent to a given substituent, but they do not distinguish the remaining remote sites. We report a strategy based on remote steric control, whereby a roof-like ligand protects the distant para site in addition to the ortho sites, and thereby enables selective activation of meta carbon-hydrogen (C-H) bonds in the absence of ortho or para substituents. We demonstrate this concept for iridium-catalyzed meta-selective borylation of various monosubstituted arenes, including complex drug molecules. This strategy has the potential to expand the toolbox of C-H bond functionalization to previously nondifferentiable reaction sites.

Automated summary

Regioselective functionalization of arenes is a challenging problem in organic synthesis. This study presents a strategy based on remote steric control, where a roof-like ligand protects the distant para site and enables selective activation of meta carbon-hydrogen (C-H) bonds.