4.6 Article

Agency Deficits in a Human Genetic Model of Schizophrenia: Insights From 22q11DS Patients

期刊

SCHIZOPHRENIA BULLETIN
卷 48, 期 2, 页码 495-504

出版社

OXFORD UNIV PRESS
DOI: 10.1093/schbul/sbab143

关键词

sense of agency; velocardiofacial syndrome; sensorimotor prediction; virtual reality; psychosis; locomotion

资金

  1. Swiss National Science Foundation (SNSF) [144260, 159968, 179404]
  2. SNSF National Center of Competence in Research (NCCR) [185897]
  3. SNSF Sinergia [125135]
  4. Bertarelli Foundation
  5. European Research Council (ERC) under the European Union [803122]
  6. European Research Council (ERC) [803122] Funding Source: European Research Council (ERC)

向作者/读者索取更多资源

This study investigated full body agency in individuals with 22q11 deletion syndrome, a genetic predisposition for schizophrenia. The results showed deficits in monitoring actions and a bias towards erroneous attribution of actions to oneself, suggesting that deficits in delineation of the self may be a precursor to psychosis.
Schizophrenia is a chronic and disabling mental illness characterized by a disordered sense of self. Current theories suggest that deficiencies in the sense of control over one's actions (Sense of Agency, SoA) may underlie some of the symptoms of schizophrenia. However, it is not clear if agency deficits are a precursor or a result of psychosis. Here, we investigated full body agency using virtual reality in a cohort of 22q11 deletion syndrome participants with a genetic propensity for schizophrenia. In two experiments employing virtual reality, full body motion tracking, and online feedback, we investigated SoA in two separate domains. Our results show that participants with 22q11DS had a considerable deficit in monitoring their actions, compared to age-matched controls in both the temporal and spatial domain. This was coupled with a bias toward erroneous attribution of actions to the self. These results indicate that nonpsychotic 22q11DS participants have a domain general deficit in the conscious sensorimotor mechanisms underlying the bodily self. Our data reveal an abnormality in the SoA in a cohort with a genetic predisposition for schizophrenia, but without psychosis, providing evidence that deficits in delineation of the self may be a precursor rather than a result of the psychotic state.

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