期刊
SCHIZOPHRENIA BULLETIN
卷 48, 期 2, 页码 485-494出版社
OXFORD UNIV PRESS
DOI: 10.1093/schbul/sbab139
关键词
schizophrenia; functional connectivity; 22q11DS; dopaminergic systems; striatal connectivity; genetic risk to psychosis
类别
资金
- Agencia Nacional de Investigacion y Desarrollo from Chile (ANID) [ANILLO PIA ACT192064, ACT1414]
- FONDECYT regular [1200601, 1191710]
- Millennium Nucleus for Cardiovascular Disease [NCN17_129]
This study used resting-state functional MRI to examine striatocortical functional connectivity in 22q11.2DS patients and found a dorsal to ventral gradient of hypo- to hyperstriatocortical connectivity related to psychosis across patient groups. The study also identified abnormal functional connectivity in the ventral striatocortical system in 22q11.2DS patients, suggesting it may be a marker of illness risk.
22q11.2 deletion syndrome (22q11.2DS) is a genetic neurodevelopmental disorder that represents one of the greatest known risk factors for psychosis. Previous studies in psychotic subjects without the deletion have identified a dopaminergic dysfunction in striatal regions, and dysconnectivity of striatocortical systems, as an important mechanism in the emergence of psychosis. Here, we used resting-state functional MRI to examine striatocortical functional connectivity in 22q11.2DS patients. We used a 2 x 2 factorial design including 125 subjects (55 healthy controls, 28 22q11.2DS patients without a history of psychosis, 10 22q11.2DS patients with a history of psychosis, and 32 subjects with a history of psychosis without the deletion), allowing us to identify network effects related to the deletion and to the presence of psychosis. In line with previous results from psychotic patients without 22q11.2DS, we found that there was a dorsal to ventral gradient of hypo- to hyperstriatocortical connectivity related to psychosis across both patient groups. The 22q11.2DS was additionally associated with abnormal functional connectivity in ventral striatocortical networks, with no significant differences identified in the dorsal system. Abnormalities in the ventral striatocortical system observed in these individuals with high genetic risk to psychosis may thus reflect a marker of illness risk.
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