4.1 Article

Spatial structure of the fibril-forming SEM1(86-107) peptide in a complex with dodecylphosphocholine micelles

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The Structure of Fibril-Forming SEM1(86-107) Peptide Increasing the HIV Infectivity

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Summary: SEM1(86-107) peptide is a cleavage product expressed in seminal vesicles, forming amyloid fibrils in semen and potentially increasing HIV infectivity. The spatial structure of SEM1(86-107) was studied using NMR and CD spectroscopy, revealing regions with random coil conformations. Analysis showed that specific fragments within the peptide are responsible for the fibrillation process.

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