4.7 Review

Serine/threonine kinase inhibition as antifibrotic therapy: transforming growth factor-beta and Rho kinase inhibitors

期刊

RHEUMATOLOGY
卷 61, 期 4, 页码 1354-1365

出版社

OXFORD UNIV PRESS
DOI: 10.1093/rheumatology/keab762

关键词

serine/threonine kinase; kinase inhibitors; fibrosis; antifibrotic treatment; TGF-beta; ROCK; TGF-beta inhibitors; ROCK inhibitors

向作者/读者索取更多资源

Serine/threonine kinases mediate phosphorylation of intracellular protein targets and play a crucial role in regulating cellular functions, including fibrosis development and maintenance in diseases. Drugs targeting and inhibiting these kinases have been developed and may serve as potential therapeutic agents for fibrotic diseases.
Serine/threonine kinases mediate the phosphorylation of intracellular protein targets, transferring a phosphorus group from an adenosine triphosphate molecule to the specific amino acid residues within the target proteins. Serine/threonine kinases regulate multiple key cellular functions. From this large group of kinases, TGF-beta through serine/threonine activity of its receptors and Rho kinase (ROCK) play an important role in the development and maintenance of fibrosis in various human diseases, including SSc. In recent years, multiple drugs targeting and inhibiting these kinases have been developed, opening the possibility of becoming potential antifibrotic agents of clinical value for treating fibrotic diseases. This review analyses the contribution of TGF-beta and ROCK-mediated serine/threonine kinase molecular pathways to the development and maintenance of pathological fibrosis and the potential clinical use of their inhibition.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据