期刊
BRAZILIAN JOURNAL OF PSYCHIATRY
卷 43, 期 6, 页码 621-630出版社
ASSOC BRASILEIRA PSIQUIATRIA
DOI: 10.1590/1516-4446-2020-1246
关键词
Bipolar disorder; major depressive disorder; comorbidities; obesity; metabolic syndrome; cardiovascular disease
类别
资金
- Pons Bartran 2020 grant [249566]
- Spanish Ministry of Science and Innovation [PI15/00283, PI18/00805]
- ISCIII-Subdireccion General de Evaluacion
- Fondo Europeo de Desarrollo Regional (FEDER)
- Instituto de Salud Carlos III [PI16/00187, PI19/00954]
- Centro de Investigacion Biomedica en Red de Salud Mental (CIBERSAM)
- Secretaria d'Universitats i Recerca del Departament d'Economia i Coneixement [2017 SGR 1365]
- CERCA Programme
- Departament de Salut de la the Generalitat de Catalunya (Pla Estrategic de Recerca i Innovacioen Salut [PERIS]) [SLT006/17/00357]
- Forest Research Institute
- Brain and Behaviour Foundation
- EU Horizon 2020
- Stanley Medical Research Institute
- Spanish Ministry of Economy, Industry and Competitiveness [PI16/00187, PI19/00954]
- ISCIII-Subdireccion General de Evaluacion y el FEDER
- Comissionat per a Universitats i Recerca del DIUE de la Generalitat de Catalunya [2017 SGR 1365]
- CERCA Programme/Generalitat de Catalunya
- FEDER
This article reviews the most common non-psychiatric comorbidities associated with affective disorders and emphasizes the significant impact of these comorbidities on the treatment and prognosis of affective disorders. These comorbidities may appear before or after the onset of affective disorders, contributing to the complexity of disease management for patients.
This article reviews the most common non-psychiatric comorbidities associated with affective disorders, examining the implications of their possible bidirectional link. A narrative review was conducted on the association among the three most common non-psychiatric diseases in major depressive disorder and bipolar disorder (obesity, metabolic syndrome, and cardiovascular diseases) in articles published from January 1994 to April 2020. The evidence suggests that obesity, metabolic syndrome, and cardiovascular diseases are highly prevalent in patients diagnosed with affective disorders. The presence of non-psychiatric comorbidities significantly worsens the therapeutic management and prognosis of affective disorders and vice versa. In many cases, these comorbidities may precede the onset of affective disorders, although in most cases they appear after it. The presence of these concurrent non-psychiatric diseases in an individual diagnosed with an affective disorder is associated with a more complex disease presentation and management. For professionals, the evidence unequivocally supports routine surveillance of comorbidities from a multidisciplinary approach.
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