期刊
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
卷 42, 期 7, 页码 1330-1337出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/IAE.0000000000003451
关键词
ultrawide-field fluorescein angiography; oral fluorescein; intravenous fluorescein; retinopathy of prematurity
资金
- Chang Gung Memorial Hospital Research Grants [CMRPG3L0151, CMRPG3I0071-3]
- Ministry of Science and Technology Research Grant [MOST 109-2314-B-182A-019-MY3]
In pediatric patients with a history of prematurity, intravenous ultrawide-field fluorescein angiography (IV FA) provides superior image quality, shorter time to dye appearance and peak fluorescence, and higher peak intensity compared to oral FA. However, oral FA remains an effective and useful alternative in this population.
Purpose: To compare between oral and intravenous (IV) ultrawide-field fluorescein angiography in pediatric patients with a history of prematurity of retinopathy or prematurity. Methods: Pediatric patients (<18 year old; n = 107 patients) who underwent ultrawide-field fluorescein angiography for retinopathy of prematurity were categorized into oral and IV fluorescein angiography (FA) groups. Quality of FA images was graded on the order of retinal vessels visible. Reported outcomes were proportions of graded FA images, peak fluorescein intensity, and the time to first dye appearance and to reach peak fluorescence. Results: Image quality analysis revealed that 91.5% of IV FA images had excellent image quality compared with only 55.6% of oral FA images (P < 0.01). There were still 83.3% of oral-contrast images with good or excellent image quality. The average time required for first dye appearance and peak fluorescence were significantly shorter in the IV FA group than in the oral FA group (P < 0.01). Peak intensity was greater in the IV group (141.41 +/- 29.09) than in the oral group (111.25 +/- 45.68; P < 0.01). Adverse reaction rates were similar between the two groups (P = 0.22). Conclusion: Ultrawide-field fluorescein angiography provides excellent-quality imaging of the retina in the pediatric population. Overall, oral FA is still an effective and useful alternative to IV FA in children with prematurity history.
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