期刊
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
卷 293, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.resp.2021.103702
关键词
Dysphagia; Radiation-associated-dysphagia; Cough; Late radiation-associated-dysphagia
资金
- NIH common fund SPARC [OT2OD023854]
- Neal Pitts Foundation
The study found reduced airflow during reflexive cough in advanced stage head and neck cancer survivors, with even lower airflow in aspirators. Surprisingly, patients recently post-treatment showed worse cough airflow compared to those further post-treatment.
Background: The aim of this study was to investigate differences in reflexive and volitional cough airflows in advanced stage head and neck cancer survivors as it relates to aspiration status and time since treatment. The hypothesis is that those who aspirate several years after treatment completion would demonstrate reduced airflows for all cough parameters compared to those recently status post treatment completion given the known progressive deterioration associated with radiotherapy. Methods: Demographic and airflow data during both reflexive and volitional cough tasks and aspiration status as determined during fiberoptic endoscopic evaluation of swallow function were collected from 33 Head and Neck Cancer (HNC) survivors. Results: Omnibus MANOVA for dependent airflow variables and independent variables aspiration status, time since treatment and cough type (reflex or volitional) was significant (F(3,1) = 184, p < 0.000) indicating that peak expiratory flow rates (PEFR) were reduced under reflex (mean PEFR 1.88 SD 0.7) versus volitional (mean PEFR 2.3, SD 0.7) cough types; reduced for aspirators versus non-aspirators (F(2,1) = 4.1, p = 0.04) and reduced for those in the subacute versus chronic phase status post Intensity Modulated Radiotherapy (IMRT) (F (2,1) = 10.05, p = 0.002). Conclusion: Findings of reduced reflexive compared to volitional cough airflows in head and neck cancer survivors are consistent with those from both healthy and other diseased populations. Additional findings that aspirators demonstrate reduced cough airflows compared to non-aspirators supports the hypothesis. Surprisingly, those recently status post treatment completion show worse cough airflows compared to those remotely status post treatment completion.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据