期刊
RESPIRATORY MEDICINE
卷 195, 期 -, 页码 -出版社
W B SAUNDERS CO LTD
DOI: 10.1016/j.rmed.2022.106777
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Non-intubated/awake surgical lung biopsy was compared to conventional VATS biopsy in patients with F-ILD. The two procedures showed similar identification of histopathological features, but awake biopsy had significantly higher patient age and diagnostic confidence. Both procedures had a 100% diagnostic yield and similar distribution of ILD diagnoses. Awake biopsy has the potential to become the standard surgical procedure in F-ILD patients, but larger studies are needed for validation.
Surgical lung biopsy remains the standard procedure for the subset of patients with fibrosing interstitial lung disease (F-ILD) who require a lung biopsy to secure a confident diagnosis. Little is known about the pathologic features of samples obtained via non-intubated/awake surgical lung biopsy and the diagnostic accuracy of awake biopsy in patients with F-ILD. Two expert thoracic pathologists blinded to the type of lung biopsy compared the clinical-pathologic features of 120 conventional VATS biopsies with those of 21 consecutive non-intubated/awake VATS biopsies. No statistically significant differences between the two procedures were observed with regard to identification of histopathological features. Biopsy length, average of sampled lobes and mean number of slides were similar with the two procedures, while the width of the biopsies was significantly deeper with conventional VATS (31.5 mm versus 25.6 mm; p = 0.01). By contrast, the mean age of patients (69.5 versus 64.5 years; p = 0.02) and the level of diagnostic confidence (100% versus 75%; p = 0.007) were significantly higher among patients undergoing the awake procedure. Diagnostic yield was 100% in both groups, with a similar distribution of ILD diagnoses. Non-intubated/awake biopsy has the potential to become the standard surgical procedure in patients with F-ILD requiring a histological confirmation of their diagnosis. However, larger prospective studies are needed to validate the safety and diagnostic yield of awake compared to conventional VATS.
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